%A Cruz,Michelle S. %A Diamond,Alani %A Russell,Astrid %A Jameson,Julie Marie %D 2018 %J Frontiers in Immunology %C %F %G English %K human,γδ T cell,skin immunity,T cell,diabetes,Alopecia Areata,Melanoma,Psoriasis %Q %R 10.3389/fimmu.2018.01304 %W %L %M %P %7 %8 2018-June-06 %9 Review %# %! Human T Cells in Skin Immunity %* %< %T Human αβ and γδ T Cells in Skin Immunity and Disease %U https://www.frontiersin.org/articles/10.3389/fimmu.2018.01304 %V 9 %0 JOURNAL ARTICLE %@ 1664-3224 %X γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata. Understanding the contribution of skin-resident and skin-infiltrating T cell populations and cross-talk with other immune cells is leading to the development of novel therapeutics for patients. However, there is still much to be learned in order to effectively modulate T cell function and maintain healthy skin homeostasis.