MINI REVIEW article
Arguing for Adaptive Clinical Trials in Sepsis
- Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Sepsis is life-threatening organ dysfunction due to dysregulated response to infection. Patients with sepsis exhibit wide heterogeneity stemming from genetic, molecular, and clinical factors as well as differences in pathogens, creating challenges for the development of effective treatments. Several gaps in knowledge also contribute: (i) biomarkers that identify patients likely to benefit from specific treatments are unknown; (ii) therapeutic dose and duration is often poorly understood; and (iii) short-term mortality, a common outcome measure, is frequently criticized for being insensitive. To date, the majority of sepsis trials use traditional design features, and have largely failed to identify new treatments with incremental benefit over standard of care. Traditional trials are also frequently conducted as part of a drug evaluation process that is segmented into several phases, each requiring separate trials, with a long time delay from inception through design and execution to incorporation of results into clinical practice. By contrast, adaptive clinical trial designs facilitate the evaluation of several candidate treatments simultaneously, learn from emergent discoveries during the course of the trial, and can be structured efficiently to lead to more timely conclusions compared to traditional trial designs. Adoption of new treatments in clinical practice can be accelerated if these trials are incorporated in electronic health records as part of a learning health system. In this review, we discuss challenges in the evaluation of treatments for sepsis, and explore potential benefits and weaknesses of recent advances in adaptive trial methodologies to address these challenges.
Sepsis is a leading cause of critical illness and mortality globally (1, 2). It is a clinical syndrome and defined as a dysregulated host response to infection resulting in organ failure (3). This definition implies that different combinations of host and pathogen characteristics and interactions among them may lead to the same clinical picture. This inherent heterogeneity presents a major challenge to develop treatments and may be an important reason for recent neutral clinical trials. In addition, the traditional sequence to develop new therapeutics by pharmaceutical companies has several limitations that may exacerbate these challenges, and lead to prolonged evaluation periods of up to a decade before results can be operationalized (4). In this review, we discuss challenges in the evaluation of treatments for sepsis, and explore potential benefits of recent advances in adaptive trial methodologies to address these challenges.
Challenges in the Evaluation of Potential Treatments
Sepsis Is Extremely Heterogeneous
Several preclinical models suggest that sepsis results from a disproportionate pro-inflammatory response to infection. However, several clinical trials of anti-inflammatory agents in relatively broad patient populations were disappointing (5). Subsequent findings indicated that circulating levels of pro-inflammatory cytokines, such as IL-6 and TNF ranged from 8 to 1,550,000 pg/ml and 7 to 57,000 pg/ml, respectively, in patients with sepsis (6). Thus, the assumption that all patients would benefit equally from anti-inflammatory agents is unlikely. The host immune response during sepsis is complex and dynamic, involving excessive pro-inflammation and immunosuppression, often concomitantly. The balance of pro- and anti-inflammatory responses also evolves over the course of illness, and may be prognostic (7, 8).
A sustained dysregulated immune response may lead to profound alterations in the endothelium and surrounding tissues, including increased leukocyte adhesion, coagulation, and vasodilation, and loss of barrier function, hypoperfusion, and tissue hypoxemia (9). These disruptions and others lead to multisystem organ dysfunction, including acute kidney injury, neurologic complications, acute respiratory distress syndrome (ARDS), hepatic failure, and shock. However, the specific organ systems affected varies between patients. This organ failure is commonly seen against a backdrop of multimorbidity, a condition where two or more comorbidities may exist in a patient. Multimorbidity is observed in more than 30% of ICU patients (10) and further increases clinical heterogeneity. Taken as a whole, such complex variability stemming from these and other sources (e.g., host genetics and microbiologic factors) poses significant challenges to the efficient design and conduct of clinical trials, particularly those testing interventions targeting a specific mechanism. Some subsets of patients may benefit from such an intervention, while others may result in no benefit or even harm. For example, in simulated trials of anti-TNF studied in silico, benefit was observed after considering genetic and microbiological factors (11). However, most trials of anti-TNF in humans have ignored these factors.
Biomarkers That Predict Treatment Response Are Unknown Before Initiating a Trial
As discussed above, sepsis pathobiology is complex and evolving. As opposed to other diseases in which the natural history and risk factors are better understood, there are critical gaps in our knowledge of the potential markers of prognosis after sepsis (i.e., prognostic markers) and markers that predict treatment response (i.e., predictive markers). This distinction between prognostic and predictive markers is critical. For example, in a trial of anti-TNF, a group of patients with high levels of IL-6 had a higher mortality rate, but not a higher drug response, suggesting prognostic but not predictive utility as a biomarker (6). In scenarios in which a treatment’s effect is meaningfully heterogeneous among the patient population, predictive markers are useful in explaining the sources of this heterogeneity of treatment effect (HTE). Without knowledge of the drivers of HTE, researchers and drug companies either ignore heterogeneity and enroll broadly or take a leap of faith and enroll narrowly based on suspected predictive biomarkers. If the biomarkers are not validated, the latter scenario could lead to exclusion of patients who would have benefited, or inclusion of patients who will not respond to the treatment.
While it is possible that single markers may be identified as sufficiently predictive by themselves, it is also possible that groups of genetic, metabolic, and/or clinical features may often occur together, forming groups or “phenotypes” of patients within the broad umbrella of sepsis that may have similar outcomes or treatment response rates. In sepsis and septic shock, phenotypes have recently been described that are associated with variable risk of mortality and would be considered “prognostic” (12, 13). In ARDS, phenotypes are described and found to respond variably to different fluid and ventilator management strategies (14). As sepsis phenotypes are further described, it will be important to allow for future trials to incorporate possible markers of HTE as efficiently as possible to avoid missing a true drug response by enrolling too broadly or too narrowly.
Optimal Therapeutic Dose and Duration Is Often Poorly Understood
The selection of treatment dosing and duration is often based on limited animal studies and small pharmacokinetic and pharmacodynamics studies in humans, with a focus on evaluating safety (15). Preclinical studies are commonly carried out in simple, often healthy and young, rodent models exposed to a specific endotoxin or using the cecal-ligation and puncture model. These models are criticized for bearing little relation to human sepsis, which occurs in older patients with significant comorbidities and who are often receiving adjuvant support. Furthermore, treatment in the rodent models has typically coincided with the timing of the infectious challenge; in humans, time between treatment and the initial infection is unknown and likely variable (5). The pitfalls of designing a phase 3 study based on an optimistic interpretation of preclinical and traditional early phase designs are suggested in the case of nitric oxide synthase inhibitor NG-monomethyl-l-arginine (L-NMMA). Promoted by encouraging preclinical data, a phase 2 safety study was conducted and showed a promising trend toward increased survival in the treated group (16). However, a subsequent phase 3 trial using a similar dosing strategy found increased mortality in the treatment arm overall, but significant survival benefit in a group with a relatively low exposure to the drug (17). The investigators concluded that this was likely a result of a relatively high exposure to the drug overall. Other studies suggest that in some cases dosing and duration may interact with each other in complex ways (11). Thus, the impact of dosing and duration, and their interaction, on sepsis outcomes is often poorly understood prior to initiation of phase 3 studies.
Short-Term Mortality Is Insensitive as a Primary Outcome
Short-term, all-cause mortality is a commonly used primary endpoint in phase 2 and 3 trials (18). However, short-term mortality is declining (19, 20), and those who do not die early often die in the ensuing months or incur considerable morbidity (21, 22). Moreover, pure mortality endpoints are criticized for being insensitive measures of biologic activity, and thus poor tools for use in early phase trials for selection of dosing and duration. Recognizing these shortcomings, there is interest in identifying and validating short-term endpoints that are both more sensitive to treatment effects and good proxies for longer-term patient centered outcomes; one proposed alternative is combination of mortality and organ support duration (23).
Novel Trial Methodologies and their Utility for Evaluation of Sepsis Treatments
Most sepsis trials use traditional design features, in which all trial parameters are fixed for the duration of the study, including randomization ratios, sample sizes, number of treatment arms, and inclusion/exclusion criteria, among others. These designs have the advantage of optimal statistical power and internal validity when there are only two treatment arms, but this comes at the expense of flexibility should the investigator be interested in testing more complex and potentially numerous hypotheses (24).
By contrast, adaptive designs facilitate the evaluation of several research questions simultaneously and embrace the possibility of emergent discoveries during the course of the trial. During an adaptive trial, updates are made to the design parameters following interim analysis, often conducted several times before the trial’s completion. The decision rules dictating which updates can be made are predetermined before initiation to avoid introducing bias (25–27). Below we discuss several features of adaptive designs that could theoretically be used to address key challenges in the evaluation of sepsis treatments (Table 1, section A). In addition, we discuss ways in which adaptive designs can potentially accelerate the drug evaluation process (summarized in the Table 1, section B).
Table 1. Comparison of traditional and adaptive design features in addressing challenges of sepsis to the evaluation of beneficial treatments (section A), and ways in which common features of each influence the total time spent evaluating treatments (section B).
Bayesian Response Adaptive Randomization (RAR)
Although it is optimal to conduct a two-arm trial using a traditional design, such approaches are inefficient when evaluating more than two treatments against control. Traditional designs typically use the frequentist statistical paradigm, where prior information about efficacy is utilized formally only in the design of a clinical trial (e.g., power calculations), but not during analyses. Alternatively, Bayesian statistical approaches provide a formal mathematical mechanism for combining prior and current information for use in the design, conduct, and final analysis stages of the trial (28). Adaptive trial designs have been developed under both frequentist and Bayesian paradigms (29).
The Bayesian paradigm provides a natural foundation for statistical tools utilized in many adaptive designs, which involve iteratively updating or “adapting” information gathered during the trial (25). One such tool, RAR, is used to increase efficiency when testing more than one treatment against control. Over the course of the trial, accumulating data are used to adjust the randomization probabilities to preferentially assign future patients to better-performing treatment arms (26). Typically, the first block of patients are randomized to each arm in equal proportion and randomization probabilities for subsequent blocks are calculated based on information accumulated prior to starting the block. A common way of executing RAR is by calculating the Bayesian predictive probability that a given treatment arm will be superior to control in the final analysis. This calculation often requires sophisticated computer simulations, but effectively integrates not only uncertainty about the true drug benefit based on data accumulated so far but also uncertainty about future data that have not yet been observed (30). Unless the predictive probability is too low (i.e., the arm should be dropped), or sufficiently high (the arm may “graduate” to the next phase of testing), the updated randomization probability for the next block of patients is proportional to the predictive probability of success for the treatment relative to control (27). Frequentist adaptive trial designs exist, but are not amenable to RAR.
Implementation of RAR could benefit sepsis trials in several ways. First, it would enable the study of multiple drugs simultaneously in a phase 2 trial, increasing the chances that at least one drug being tested will improve outcomes while reducing the time and costs needed to evaluate them individually by “learning” which ones are superior during the phase 2 trial and will have high likelihood of success in future phase 3 trials. The use of RAR instead of fixed randomization ratios underscores a focus on identifying the best-performing arm, instead of expending resources to rank all arms from worst to best performance. Second, instead of using RAR to assign patients to different arms, phase 2 adaptive trials could test different dosing and/or duration strategies for a single drug to better inform the optimal treatment strategy for phase 3 testing. This approach was implemented in SEPSIS-ACT, an adaptive trial of selepressin dosing strategies in adults with septic shock (31). In this trial, RAR was used to allocate patients to three dose levels until predefined checkpoints for safety and efficacy were triggered. If necessary, a fourth could be introduced based on response to the three doses.
Adaptive Enrichment Designs
Often there is interest in a variety of drugs as well as identifying potential sub-populations within which the drugs are most effective. In a traditional enrichment design, randomization is simply limited to patients with a specific biomarker profile known to be predictive of treatment response. However, we may not know which patient groups may benefit the most from a treatment in sepsis. Using adaptive trial methodologies, it is possible to incorporate putative predictive biomarkers to “learn” the optimal biomarker profile in the case that a meaningful underlying HTE exists (32).
In one approach, the RAR algorithm is used in an adaptive platform trial (see below) of several drugs, where patients are categorized into several candidate predictive biomarker strata before randomization. In the BATTLE I trial, non-small cell lung cancer patients were classified into four candidate strata defined by genomic and expression markers before being randomized to one of four drug regimens. Separately for each stratum, the RAR weights were adjusted as data accumulated to favor assignment of drugs with higher within-stratum response rates (33). The results from BATTLE 1 both confirmed pre-specified hypotheses of treatment efficacy in the presence of individual markers related to the treatments’ mechanism of action, and also suggested new treatment–biomarker interactions (34).
An alternative enrichment approach allows for more flexibility in the scenario where candidate predictive biomarkers have not been identified. In this framework, the optimal target population for the experimental treatment is adaptively learned and estimated as a function of baseline covariates (35, 36). Such designs could be useful, for example, to identify the optimal threshold value of a predictive biomarker to use for splitting the patient population into responsive and non-responsive strata (35).
While underlying drug response strata may exist and may be delineated by putative biomarkers, demonstrating this may be difficult in scenarios where treatment effects are relatively homogeneous or when the overall treatment effect is small. Thus, adaptive enrichment strategies present a potential advantage by incorporating mechanisms to adapt to the presence of HTE if evidence for it mounts over the course of the trial.
The traditional drug evaluation pipeline is usually segmented into several phases, each involving a brand new trial. To streamline this process and reduce associated time and costs, a number of designs have been developed that combine multiple phases into a single trial, including several within the Bayesian adaptive framework (37). This approach was implemented into the SEPSIS-ACT trial, an adaptive phase 2b/3 trial (31). Part 1 of SEPSIS-ACT uses RAR to “learn” which dosing regimen leads to greatest efficacy, while part 2 is a confirmation stage randomizing 1,000 new patients equally between control and a single treatment arm featuring the dose selected in part 1. Early stopping of part 1 would occur if enough evidence had been obtained to select an optimal dose; otherwise enrollment would continue up to a predetermined maximum sample size. To further increase efficiency, all data from parts 1 and 2 are incorporated in the final analysis. Thus, adaptive seamless designs may lead to more timely conclusions, an advantage which is just as useful for patients and researchers in the case of a truly effective treatment as for a truly ineffective one.
Adaptive Platform Trials
There is significant effort required to launch a trial, including preparing trial documents, identifying sites, initiating the trial, and obtaining regulatory approval. As the name suggests, the adaptive platform trial is capable of being a platform for testing experimental treatments in a perpetual manner via a common master protocol, by dropping treatments lacking efficiency and adding new treatments going into the future. They are able to incorporate several design features of adaptive trials, such as RAR, biomarker enrichment, and seamless transitioning, often all in the same design. Currently there are platform trials enrolling patients in oncology (38, 39), infectious diseases (40), neurology (41), and intensive care (42).
In a platform trial, the feedback loop involving collecting data, updating the Bayesian statistical model and updating RAR weights is modified to enable new arms to be added, and old arms to either be dropped or “graduate” to the next phase of testing. A schematic of the platform trial design is shown in the Figure 1. I-SPY 2 is a phase 2 platform trial in women with locally advanced breast cancer, and out of eight treatments entered into the trial loop so far, two are considered promising enough to “graduate” out of the trial (43, 44). GBM-AGILE, an inferentially seamless phase 2/3 platform trial in glioblastoma, was designed so that “graduating” treatments are seamlessly transitioned into phase 3 confirmatory testing (39). Both I-SPY 2 and GBM-AGILE incorporate enrichment biomarkers hypothesized to be predictive of response for specific treatment arms.
Figure 1. Schematic representation of a hypothetical adaptive platform trial. An initial block of patients is stratified based on known or candidate predictive biomarkers, and then randomized to an experimental or control arm. Once a predefined number of patients is enrolled, outcomes are observed and the data are input to the Bayesian statistical model by arm and stratum, which is used to calculate the predictive probabilities (PP) that each experimental arm will be superior to control in the final analysis. These PP are checked against predefined decision boundaries established so that arms with poor probability of success are dropped, and arms with high probability of success “graduate” to the next phase of testing. Arms with PP that do not require dropping or graduation continue enrolling subjects; arms that are removed may be replaced by new experimental treatments, accrual permitting. Finally, the PP are used to update randomization probabilities used for the next block of patients to be enrolled, and the feedback loop begins anew.
There is considerable pressure to identify short-term endpoints that can be used to speed the evaluation of treatments by accurately predicting treatment response in terms of a gold-standard endpoint, such as long-term mortality. I-SPY 2 and GBM-AGILE both leverage accumulating data in a continually updated Bayesian longitudinal model to generate predictions of the long-term endpoints for use in updating RAR weights (26, 30, 45). In I-SPY 1, for example, it was found that MRI outcomes within the first few weeks following treatment predicted pathological complete response (pCR) at the time of surgery, about 5 months after treatment (46). Thus, short-term MRI data are used to predict pCR in I-SPY 2 for the purposes of updating the RAR weights months before the actual pCR data are observed, increasing efficiency (38, 46). In GBM-AGILE, useful proxy endpoints are being learned and vetted within the trial, and potentially different endpoints are expected to capture the effects of different treatments (39, 45).
The incorporation of Bayesian models in adaptive sepsis trials could theoretically provide a means of evaluating how changes in short-term endpoints (e.g., 28-day organ failure free days) due to treatment correspond with changes in new long-term endpoints such as quality-adjusted life-years at 6 months.
Embedded, Multifactorial Adaptive Platform Trials
Randomized, embedded, multifactorial adaptive platform (REMAP) trials utilize all of the features of a perpetual adaptive platform trials like I-SPY 2 or GBM-AGILE, the key distinction being that a REMAP trial is executed directly within clinical practice through the electronic medical record [EMR (47)]. A key advantage of embedding trials in clinical care is to create a “learning health system” by enrolling most eligible participants, which increases the speed with which new knowledge is generated and implemented in routine clinical care. In addition, it maximizes internal and external validity, and minimizes operational complexity at the bedside (there is no need to distinguish between trial and non-trial patients, because all patients are trial patients). While screening and recruitment for a REMAP can be conducted by research staff, it is not intended that recruitment should be dependent on research staff because they are typically present during office hours. Thus, REMAP trials may reduce costs.
Most REMAP trials determine the effectiveness of various treatments used in routine clinical care but in a randomized setting. An example is the REMAP-CAP trial being conducted in patients with community-acquired pneumonia severe enough to be admitted to an intensive care unit (42). Upon submitting treatment orders through the EMR, the clinician can choose to instead be randomized the most promising treatment regimens (utilizing RAR weights). To capture the clinical complexity of treatment plans involving combinations of treatments, patients are randomized to multiple sets of treatments within different domains. For instance, different antibiotic regimens and immunomodulatory drugs may be compared in patients with severe pneumonia. This complexity not only requires the use of complex statistical models incorporating interaction terms but also increases penetration of the trial through its embedment in the EMR. Like I-SPY 2 and GMB-AGILE, REMAP-CAP is designed to be perpetual, and as such include mechanisms to incorporate control arms that are updated to incorporate any newly discovered standards of care, e.g., resulting from the trial itself. Although not implemented yet in REMAP-CAP, there is also the capability to incorporate enrichment biomarkers as well. Investigators have recently been funded to launch REMAP initiatives in other conditions, including anti-microbial resistance, cystic fibrosis, hepatitis C, and operative stress in the elderly.
Inherent Challenges of Adaptive Designs
Adaptive designs may have many promising features for future trials in sepsis, but they also come with their own challenges. Statistical models and the exploration of operating characteristics are complex and simulation-intensive. Selection of potential trial trajectories is especially important during the simulation process, as an overly narrow set of scenarios may lead researchers to fail to understand the consequences of their design choices. A range of alternative trajectories should be explored by varying important simulation parameters, for example: choice of Bayesian prior (assuming a Bayesian model is used); choice of data model; underlying treatment effects for each arm; proportions of patients within subtypes; accrual rates; and others. For designs relying on simulation-based outcome metrics such as the predictive probability of success, failure to explore sensitivity to modeling assumptions may pose risk to future patients, e.g., if drugs are erroneously selected for graduation. In designs considering many subgroups or combinations of drugs, careful consideration must be taken to craft statistical models with only the necessary complexity to preserve statistical power. In addition, the benefits to trial efficiency of periodically updating RAR weights are somewhat dependent on patient accrual rates; if accrual of data occurs faster compared to ideal updating time, RAR updates may occur based on incomplete follow-up. The complexity of these designs also creates difficulties communicating their features to important stakeholders who may be unfamiliar with them, such as funding agencies, institutional review boards, patients, research journals, and clinicians.
Many studies employing Bayesian adaptive trial designs have already led to promising discoveries in several diseases, including the identification of two promising candidate drugs in breast cancer. These studies leverage several key features of adaptive designs, including RAR, enrichment methods, seamless transitioning between trial phases, perpetual platforms for ongoing evaluation of candidate treatments, integration within the EMR, and others. These features are well suited to address the many challenges presented by complex, heterogeneous diseases, yet are rarely utilized in sepsis. Adoption of these designs may aid in the efficient identification of promising treatments for sepsis.
All authors contributed to the editing and preparation of this manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: sepsis, adaptive clinical trials, Bayesian statistics, platform trials, response adaptive randomization
Citation: Talisa VB, Yende S, Seymour CW and Angus DC (2018) Arguing for Adaptive Clinical Trials in Sepsis. Front. Immunol. 9:1502. doi: 10.3389/fimmu.2018.01502
Received: 01 May 2018; Accepted: 18 June 2018;
Published: 28 June 2018
Edited by:Thierry Roger, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland
Reviewed by:Thorsten Brenner, Universitätsklinikum Heidelberg, Germany
Patricia Bozza, Fundação Oswaldo Cruz, Brazil
Copyright: © 2018 Talisa, Yende, Seymour and Angus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sachin Yende, email@example.com