%A Takatori,Hiroaki %A Makita,Sohei %A Ito,Takashi %A Matsuki,Ayako %A Nakajima,Hiroshi %D 2018 %J Frontiers in Immunology %C %F %G English %K IL-33,ST2,Innate lymphoid cells (ILCs),Epithelial Cells,regulatory T cells %Q %R 10.3389/fimmu.2018.02004 %W %L %M %P %7 %8 2018-September-04 %9 Mini Review %# %! Inhibition of IL-33-ST2 axis in allergy %* %< %T Regulatory Mechanisms of IL-33-ST2-Mediated Allergic Inflammation %U https://www.frontiersin.org/articles/10.3389/fimmu.2018.02004 %V 9 %0 JOURNAL ARTICLE %@ 1664-3224 %X Interleukin-33 (IL-33) plays multiple roles in tissue homeostasis, prevention of parasitic infection, and induction of allergic inflammation. Especially, IL-33-ST2 (IL-1RL1) axis has been regarded as the villain in allergic diseases such as asthma and atopic dermatitis and in autoimmune diseases such as rheumatoid arthritis. Indeed, a number of studies have indicated that IL-33 produced by endothelial cells and epithelial cells plays a critical role in the activation and expansion of group 2 innate lymphoid cells (ILC2s) which cause allergic inflammation by producing large amounts of IL-5 and IL-13. However, mechanisms that antagonize IL-33-ST2-mediated allergic responses remain largely unknown. Recently, several groups including our group have demonstrated cellular and molecular mechanisms that could suppress excessive activation of ILC2s by the IL-33-ST2 axis. In this review, we summarize recent progress in the regulatory mechanisms of IL-33-ST2-mediated allergic responses. Selective targeting of the IL-33-ST2 axis would be a promising strategy in the treatment of allergic diseases.