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Front. Immunol. | doi: 10.3389/fimmu.2018.02009

Translational investigation of the therapeutic potential of cannabidiol (CBD): Towards a new age

  • 1Department of Neurosciences and Behaviour, Universidade de São Paulo, Brazil
  • 2Department of Pharmacology, Universidade de São Paulo, Brazil

Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, posttraumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson. Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings.

Keywords: anxiolytic, antiepileptic, Neuroprotection, Cannabidiol, Cannabis, cbd

Received: 09 Oct 2017; Accepted: 14 Aug 2018.

Edited by:

Jordi Riba, Sant Pau Institute for Biomedical Research, Spain

Reviewed by:

Esther Melamed, University of Texas at Austin, United States
Mark Ware, McGill University, Canada  

Copyright: © 2018 Crippa, Zuardi, Guimaraes and Campos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. José Alexandre Crippa, Universidade de São Paulo, Department of Neurosciences and Behaviour, São Paulo, Brazil, jcrippa@fmrp.usp.br