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Front. Immunol. | doi: 10.3389/fimmu.2018.02169

Determination of T follicular helper cell fate by dendritic cells

  • 1Jackson Laboratory for Genomic Medicine, United States
  • 2UCONN Health, United States
  • 3Yale School of Medicine, Yale University, United States
  • 4AstraZeneca (Sweden), Sweden
  • 5Sahlgrenska Academy, University of Gothenburg, Sweden

T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfhs require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DCs subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability for multiple DCs subsets and related lineages to support the Tfh differentiation program.

Keywords: TFH, dendritic cell, immunization method, Antigen dose, antigen targeting, DC subsets

Received: 16 Jun 2018; Accepted: 03 Sep 2018.

Edited by:

Shahram Salek-Ardakani, Pfizer (United States), United States

Reviewed by:

Dirk Baumjohann, Ludwig-Maximilians-Universität München, Germany
Vassili Soumelis, Institut Curie, France  

Copyright: © 2018 Williams, Eisenbarth, Krishnaswamy, Alsen and Ylrid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Adam Williams, Jackson Laboratory for Genomic Medicine, Farmington, CT, United States, adam.williams@jax.org