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Front. Immunol. | doi: 10.3389/fimmu.2018.02205

Lipid-reactive T Cells in Immunological Disorders of the Lung

  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, South Korea
  • 2Institute of Allergy and Clinical Immunology, Seoul National University College of Medicine, South Korea
  • 3Department of Microbiology and Immunobiology, Harvard Medical School, United States
  • 4Life Sciences and Biotechnology, Korea University, South Korea

Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders as well as protection of the host from pathogens. While the prevalent view of pulmonary T cell responses relies on the peptide recognition by antigen receptors, called T cell receptor (TCR)s, on the T cell surface in the context of classical Major Histocompatibility Complex (MHC), novel pathways involving the presentation of lipid antigens by cluster of differentiation 1 (CD1) molecules to lipid-reactive T cells are emerging as the key players of the pulmonary immune system. Whereas the genetic conservation of group II CD1 (CD1d) in mouse and human genomes allowed numerous in vivo studies of CD1d-restricted invariant Natural Killer T (iNKT) cells in lung diseases, the physiological roles of group I CD1 (CD1a-c) in lung immunity are only recently being understood due to the development of human CD1-transgenic mice. In this review, we will discuss the current understanding of the biology of CD1-reactive T cells with a specific focus on their roles in several pulmonary disorders.

Keywords: Pulmonary disorders, lipid antigens, CD1 molecules, CD1-restricted T cells, natural killer T cells

Received: 03 Jun 2018; Accepted: 05 Sep 2018.

Edited by:

Luc Van Kaer, Vanderbilt University, United States

Reviewed by:

François TROTTEIN, Centre national de la recherche scientifique (CNRS), France
Seddon Y. Thomas, National Institute of Environmental Health Sciences (NIEHS), United States
Mark L. Lang, University of Oklahoma Health Sciences Center, United States  

Copyright: © 2018 Ryu, Park, Kim and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
PhD. Hye Young Kim, Seoul National University College of Medicine, Department of Biomedical Sciences, Seoul, South Korea,
PhD. Ji Hyung Kim, Korea University, Life Sciences and Biotechnology, Seoul, South Korea,