%A Schmidts,Andrea %A Maus,Marcela V. %D 2018 %J Frontiers in Immunology %C %F %G English %K Immunotherapy,CAR-T cells,Cancer,Solid tumor,Toxicity,Cell Engineering %Q %R 10.3389/fimmu.2018.02593 %W %L %M %P %7 %8 2018-November-08 %9 Review %# %! CAR T cells for solid tumors %* %< %T Making CAR T Cells a Solid Option for Solid Tumors %U https://www.frontiersin.org/articles/10.3389/fimmu.2018.02593 %V 9 %0 JOURNAL ARTICLE %@ 1664-3224 %X Adoptive cell therapy with chimeric antigen receptor (CAR) T cells aims to redirect the patient's own immune system to selectively attack cancer cells. To do so, CAR T cells are endowed with specific antigen recognition moieties fused to signaling and costimulatory domains. While this approach has shown great success for the treatment of B cell malignancies, response rates among patients with solid cancers are less favorable. The major challenges for CAR T cell immunotherapy in solid cancers are the identification of unique tumor target antigens, as well as improving CAR T cell trafficking to and expansion at the tumor site. This review focuses on combinatorial antigen targeting, regional delivery and approaches to improve CAR T cell persistence in the face of a hostile tumor microenvironment.