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Front. Immunol. | doi: 10.3389/fimmu.2018.02596

Expression and function of IL-33/ST2 axis in the central nervous system under normal and diseased conditions

karen Fairlie-Clarke1, Mark Barbour1, Chelsey Wilson1, Shehla Hridi1, Debbie Allan1 and  Hui-Rong Jiang1*
  • 1University of Strathclyde, United Kingdom

Interleukin-33 (IL-33) is a well-recognised immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pathological conditions. Indeed emerging evidence from over a decade’s research suggests that IL-33 acts as one of the key molecular signalling cues coordinating the network between the immune and CNS systems, particularly during the development of neurological diseases. Here, we highlight the recent advances in our knowledge regarding the distribution and cellular localisation of IL-33 and its receptor ST2 in specific CNS regions, and more importantly the key roles IL-33/ST2 signalling pathway play in CNS function under normal and diseased conditions.

Keywords: IL-33, ST2, Central Nervous System, Neurological Diseases, Expression

Received: 03 Aug 2018; Accepted: 22 Oct 2018.

Edited by:

Detlef Neumann, Hannover Medical School, Germany

Reviewed by:

Jorg H. Fritz, McGill University, Canada
Fouad Zouein, American University of Beirut, Lebanon
Christopher J. Nile, University of Glasgow, United Kingdom  

Copyright: © 2018 Fairlie-Clarke, Barbour, Wilson, Hridi, Allan and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Hui-Rong Jiang, University of Strathclyde, Glasgow, United Kingdom, huirong.jiang@strath.ac.uk