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Non-Coding RNAs and Graft versus Host Disease

Editorial ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2018.02713

Editorial for the Review series "Non-Coding RNAs and Graft versus Host Disease"

  • 1University of Michigan, United States
  • 2University of Freiburg, Germany

Acute graft-versus-host disease (GVHD) causes activation of multiple pro-inflammatory pathways in a diverse array of immune cell subsets that are often regulated by micro RNAs (miRs). MiRs are small non-coding RNAs that post transcriptionally regulate gene expression and thereby impact inflammatory events at multiple levels including the release cytokines, chemokines, signalling by their receptors, cell-cycling, migration and filament stabilization. Multiple inflammation-related miR-target genes are described, and while some miRs target anti-inflammatory genes other promote inflammation by targeting immunosuppressive genes. Additionally, the same miR can have different effects by preferentially targeting certain genes depending on the cell type and their context, in which the miR is analyzed. Through these diverse effects in various critical immune cell subsets miRs play critical functional role in GVHD and graft-versus-leukemia effects (GVL). Thus miRs are potentially attractive targets for the modification of allogeneic immune responses using miR mimics and inhibitors. Additionally, miR-levels in different body fluids could help to guide clinical decision making and function as biomarkers to predict or diagnose GVHD. This review-series authored by experts in the field, describes the pleomorphic function of different miRs as potent regulators of multiple pro- or anti-inflammatory target genes, in various immune cell subsets that affect alloimmunity and GVHD. A better understanding of the miR-biology may help to mitigate GVHD and augment GVL effects and improve the outcomes after allogeneic hematopoietic transplantation.

Keywords: GvHD, micro RNA, Inflammation, non-coding RNAs, T cell

Received: 16 Oct 2018; Accepted: 05 Nov 2018.

Edited by:

Antoine Toubert, Paris Diderot University, France

Copyright: © 2018 Reddy and Zeiser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Robert Zeiser, University of Freiburg, Freiburg, Germany, robert.zeiser@uniklinik-freiburg.de