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Front. Immunol. | doi: 10.3389/fimmu.2018.02735

Association of diverse genotypes and phenotypes of immune cells and immunoglobulins with the course of HIV-1 infection

  • 1School of Medicine, New York University, United States
  • 2University of South China, China

The variation of disease progression among HIV-1 infected individuals draws great interest in exploring the underlying mechanisms. Studies have demonstrated that many factors are involved in the distinct disease outcome from innate to adaptive immune response, cell-mediated to humoral mediated immune response, and genetic to phenotypic factors. All elements involving in disease outcome work in concert with each other. The present data suggest that the multifaceted factors in an infected individual should be considered as a whole instead of a unique element and the analysis should be dissected in more detail for meeting the requirement of personalized medicine and better guiding of vaccine design. However, contrary to the necessity of comprehensive investigation, a problem stems from the widely used ART treatment, which influences the implementation of the studies on systematic analysis of the HIV-1 infected population, resulting in fewer data to be acquired in the future. Given a limited number of treatment-naive HIV-1 infected individuals on the way, the review endeavors to recapitulate the distinct genotype and phenotype features of the immune system with a particular focus on the surface proteins on immune cells among individuals with different HIV infection outcomes.

Keywords: HIV-1, HIV-1 disease progression, immune cells, Surface proteins, immunoglobulin, Genotype

Received: 20 Jul 2018; Accepted: 06 Nov 2018.

Edited by:

Aurelio Cafaro, Istituto Superiore di Sanità (ISS), Italy

Reviewed by:

Cristian Apetrei, University of Pittsburgh, United States
Christiane Moog, Institut National de la Santé et de la Recherche Médicale (INSERM), France  

Copyright: © 2018 Li, Liu and Gorny. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Liuzhe Li, School of Medicine, New York University, New York City, United States, liuzhe.li@nyumc.org