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Front. Immunol. | doi: 10.3389/fimmu.2018.02739

Organ-specific Neutrophil Recruitment

  • 1Ludwig-Maximilians-Universität München, Germany
  • 2Institut für kardiovaskuläre Prävention, Klinikum der Universität München, Germany

Immune responses are dependent on the recruitment of leukocytes to the site of inflammation. The classical leukocyte recruitment cascade, consisting of capture, rolling, arrest, adhesion, crawling and transendothelial migration, is thoroughly studied but mostly in model systems, such as the cremasteric microcirculation. This cascade paradigm, which is widely accepted, might be applicable to many tissues, however recruitment mechanisms might substantially vary in different organs. Over the last decade, several studies shed light on organ-specific mechanisms of leukocyte recruitment. An improved awareness of this matter opens new therapeutic windows and allows targeting inflammation in a tissue-specific manner. The aim of this review is to summarize the current understanding of the leukocyte recruitment in general and how this varies in different organs. In particular we focus on neutrophils, as these are the first circulating leukocytes to reach the site of inflammation. Specifically, the recruitment mechanism in large arteries, as well as vessels in the lungs, liver and kidney will be addressed.

Keywords: Neutrophil, recruitment, Lung, Liver, Kidney, Aorta, organ-specific, Inflammation

Received: 03 Sep 2018; Accepted: 07 Nov 2018.

Edited by:

Susanna C. Fagerholm, University of Helsinki, Finland

Reviewed by:

María J. Sanz, University of Valencia, Spain
Christian D. Sadik, Universität zu Lübeck, Germany  

Copyright: © 2018 Soehnlein, Maas and Viola. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mrs. Sanne L. Maas, Institut für kardiovaskuläre Prävention, Klinikum der Universität München, Munich, 80336, Bavaria, Germany, Sanne.Maas@med.uni-muenchen.de