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Front. Immunol. | doi: 10.3389/fimmu.2018.03027

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in drug hypersensitivity reactions

  • 1Jagiellonian University Medical College, Poland
  • 2Jagiellonian University, Poland

The human orthologue MRGPRX2 and the mice orthologue, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g. neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to activate these receptors under in vitro experimental conditions, what results in mast cell degranulation. The above drugs are also known to cause IgE-mediated anaphylactic reactions in allergic patients. The new findings on mechanisms of drug-induced mast cell degranulation may modify the current management of drug hypersensitivity reactions. Clinical interpretation of mild drug-provoked hypersensitivity reactions, interpretation of skin test with a drug of interest or further recommendations for patients suspected of drug allergy are likely to be reconsidered. In the paper we discussed future directions in research on identification and differentiation of MRGPRX2-mediated and IgE-dependent mast cell degranulation in patients presenting clinical features of drug-induced hypersensitivity reactions.

Keywords: Anaphylaxis, Drug allergy, Drug Hypersensitivity, Mast Cells, MRGPRX2

Received: 04 Jul 2018; Accepted: 06 Dec 2018.

Edited by:

Craig M. Schramm, School of Medicine, University of Connecticut, United States

Reviewed by:

Margarita Martin, University of Barcelona, Spain
Werner Pichler, Medizinische Fakultät, Universität Bern, Switzerland  

Copyright: © 2018 Porebski, Kwiecien, Pawica and Kwitniewski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Mateusz Kwitniewski, Jagiellonian University, Kraków, 31-007, Lesser Poland, Poland, mateusz.kwitniewski@uj.edu.pl