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Front. Immunol. | doi: 10.3389/fimmu.2018.03031

Severe eosinophilia in myelodysplastic syndrome with a defined and rare cytogenetic abnormality

  • 1Faculty of Medicine, Kindai University, Japan
  • 2Kindai University, Japan

Myelodysplastic syndromes (MDS) are a heterogeneous group clonal disorders of hematopoietic stem cells (HSC) characterized by ineffective hematopoiesis that lead to variable grades of impaired blood cell production. Chromosomal aberrations are often detected in MDS patients and thus cytogenetic analysis is useful for the diagnosis of these disorders. Common recurring chromosomal defects, such as the -5/5q- and -7/7q- are relatively well characterized cytogenetic abnormalities in MDS, however, the biological significance of uncommon cytogenetic alterations is unknown. We report here, two cases of peripheral blood and bone marrow hypereosinophilia in patients with MDS harboring the unbalanced translocation der(1;7)(q10;p10), a poorly characterized cytogenetic abnormality that is found in certain myeloid malignancies, including MDS. The patients reported here presented hypereosinophilia that was refractory to steroids and cytotoxic therapy, leading to severe target tissue damage that ultimately resulted in fatal end-organ failure. Potential roles of the der(1;7)(q10;p10) aberrations in the pathogenesis of aggressive eosinophilia and disease prognosis are discussed here.

Keywords: Eosinophilia, Cytogenetic (CG) analyses, Eosinophilic pneumonia, myelofibrosis, membranoproliferative glomerulonephritis (MPGN), Myelodisdplastic /myeloproliferative disorders

Received: 05 Jul 2018; Accepted: 07 Dec 2018.

Edited by:

Shigeharu Ueki, Akita University Graduate School of Medicine, Japan

Reviewed by:

Dalil Hannani, UMR5525 Techniques de l'Ingénierie Médicale et de la Complexité Informatique, Mathématiques et Applications, Grenoble (TIMC-IMAG), France
Kushagra Bansal, Harvard Medical School, United States  

Copyright: © 2018 Rai, Espinoza, Morita, Tanaka and Matsumura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. J. Luis Espinoza, Kindai University, Higashi-osaka, Japan, luis@med.kindai.ac.jp