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This article is part of the Research Topic

Lymphocyte Functional Crosstalk and Regulation

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.00360

Cross-talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis

  • 1Stony Brook University, United States

Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive immune responses. By displaying bacterial and tumorigenic antigens on their surface via major histocompatibility complexes, APCs can directly influence the differentiation of T cells. Likewise, T cell activation, differentiation, and effector functions are modulated by APCs utilizing multiple mechanisms. The objective of this review is to describe how APCs interact with and influence the activation of T cells to maintain innate immunity during exposure to microbial infection and malignant cells. How bacteria and cancer cells take advantage of some of these interactions for their own benefit will also be discussed. While this review will cover a broad range of topics, a general focus will be held around pathogens, cancers, and interactions that typically occur within the gastrointestinal tract.

Keywords: APC, CRC, TLR, PAMP, SCFA (short chain fatty acids), SFB

Received: 30 Aug 2018; Accepted: 12 Feb 2019.

Edited by:

Raghvendra M. Srivastava, Memorial Sloan Kettering Cancer Center, United States

Reviewed by:

Dan A. Mitchell, University of Warwick, United Kingdom
Derek Pociask, Tulane University School of Medicine, United States  

Copyright: © 2019 Kumar and Gaudino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Pawan Kumar, Stony Brook University, Stony Brook, United States,