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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.00364

IL33: Roles in Allergic Inflammation and Therapeutic Perspectives

 Ben Chan1, Christopher W. Lam2,  Lai-Shan Tam1 and  CK Wong1*
  • 1The Chinese University of Hong Kong, China
  • 2Macau University of Science and Technology, Macau

Interleukin (IL)-33 is a member of the IL-1 cytokine family constitutively expressed in structural and lining cells including fibroblasts, endothelial cells and epithelial cells of skin, gastrointestinal tract and lungs that are exposed to the environment. Different from most cytokines that are actively secreted from cells, nuclear cytokine IL-33 is released passively during cell necrosis or when tissues are damaged, suggesting that it may function as an alarmin that alerts the immune system after endothelial or epithelial cell damage during trauma, physical stress or infection. IL-33 plays important roles in type-2 innate immunity via activation of allergic inflammation-related eosinophils, basophils, mast cells and group 2 innate lymphoid cells (ILC2s) through its receptor ST2. In this review, we focus on the recent advances of the underlying intercellular and intracellular mechanisms by which IL-33 can regulate the allergic inflammation in various allergic diseases including allergic asthma and atopic dermatitis. The future pharmacological strategy and the application of traditional Chinese medicines targeting the IL-33/ST2 axis for anti-inflammatory therapy of allergic diseases will also be discussed.

Keywords: IL-33, allergic inflammation, Signal Transduction, Eosinophils, Mast Cells, Innate lymphoid cells (ILC), Chinese herbal medicine, Therapeutics, Alarmins

Received: 18 May 2018; Accepted: 12 Feb 2019.

Edited by:

Rong Mu, Peking University People's Hospital, China

Reviewed by:

Remo C. Russo, Federal University of Minas Gerais, Brazil
Dong Li, Jilin University, China  

Copyright: © 2019 Chan, Lam, Tam and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. CK Wong, The Chinese University of Hong Kong, Shatin, China,