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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.00518

The interplay between lymphatic vessels and chemokines

  • 1Peter MacCallum Cancer Centre, Australia
  • 2St Vincents Institute of Medical Research, Australia
  • 3Department of Microbiology and Immunology, University of Melbourne, Australia

Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the immune system. They are categorised functionally as either homeostatic, constitutively produced by tissues for basal levels of cell migration, or inflammatory, where they are generated in association with a pathological inflammatory response. While the extravasation of leukocytes via blood vessels is a key step in cells entering the tissues, the lymphatic vessels also serve as a conduit for cells that are recruited and localised through chemoattractant gradients. Furthermore, the growth and remodelling of lymphatic vessels in pathologies is influenced by chemokines and their receptors expressed by lymphatic endothelial cells in and around the pathological tissue. In this review we summarise the diverse role played by specific chemokines and their receptors in shaping the interaction of lymphatic vessels, immune cells and other pathological cell types in physiology and disease.

Keywords: chemokine, lymphatics, endothelial, chemokine receptor, Lymphangiogenesis, Lymphatic remodeling

Received: 21 Dec 2018; Accepted: 26 Feb 2019.

Edited by:

Amanda W. Lund, Oregon Health & Science University, United States

Reviewed by:

Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Bernahrd RYFFEL, Centre National de la Recherche Scientifique (CNRS), France  

Copyright: © 2019 Stacker, Farnsworth, Karnezis, Maciburko and Mueller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Steven A. Stacker, Peter MacCallum Cancer Centre, Melbourne, Australia, steven.stacker@petermac.org
Dr. Rae H. Farnsworth, Peter MacCallum Cancer Centre, Melbourne, Australia, rae.farnsworth@petermac.org