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This article is part of the Research Topic

Lymphocyte Functional Crosstalk and Regulation

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.00617

BTLA/HVEM signaling: Milestones in research and role in chronic hepatitis B virus infection

  • 1Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, China
  • 2Quanzhou 1st Hospital Affiliated to Fujian Medical University, China

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection.

Keywords: B and T lymphocyte attenuator, Herpes virus entry mediator, Hepatitis B virus, milestones, T lymphocyte

Received: 23 Oct 2018; Accepted: 08 Mar 2019.

Edited by:

Anil Shanker, Meharry Medical College, United States

Reviewed by:

Adam J. Gehring, University Health Network (UHN), Canada
Ranjit Chauhan, Memorial University of Newfoundland, Canada  

Copyright: © 2019 Yu, Zheng, Mao, Su and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Xueping Yu, Huashan Hospital Affiliated to Fudan University, Department of Infectious Diseases, Shanghai, China,
Prof. Jiming Zhang, Huashan Hospital Affiliated to Fudan University, Department of Infectious Diseases, Shanghai, China,