Corrigendum: Phagocytosis in the Brain: Homeostasis and Disease
- 1Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada
- 2Division of Brain Sciences, Department of Medicine Hammersmith Hospital, Imperial College London, London, United Kingdom
A Corrigendum on
Phagocytosis in the Brain: Homeostasis and Disease
by Galloway, D. A., Phillips, A. E. M., Owen, D. R. J., and Moore, C. S. (2019). Front. Immunol. 10:790. doi: 10.3389/fimmu.2019.00790
In the original article, there was a mistake in Figure 1, as well as its legend, as published. It was incorrectly stated that microglia remove “apoptotic oligodendrocyte progenitor cells (OPCs)” instead of “apoptotic oligodendrocytes.” The corrected Figure 1 and its legend appears below.
Figure 1. Microglial Phagocytosis in the CNS. During development, microglial phagocytosis is essential for the refinement of excessive synapses, as well as the removal of apoptotic neurons and oligodendrocytes that are overproduced during development. Homeostatic microglia in the adult brain constantly survey the brain's parenchyma, contributing to synaptic plasticity and phagocytosing apoptotic progenitor cells. With advanced age, microglia undergo senescence, display impaired debris clearance, and excessively prune synapses. In diseases, such as Alzheimer's or multiple sclerosis, microglia act as key contributors to pathology, which is partially mediated by phagocytosis of substrates, such as amyloid-β or myelin debris (made in ©BioRender - biorender.com).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: phagocytosis, microglia, macrophage, neurodegeneration, neuroinflammation
Citation: Galloway DA, Phillips AEM, Owen DRJ and Moore CS (2019) Corrigendum: Phagocytosis in the Brain: Homeostasis and Disease. Front. Immunol. 10:1575. doi: 10.3389/fimmu.2019.01575
Received: 21 June 2019; Accepted: 24 June 2019;
Published: 10 July 2019.
Copyright © 2019 Galloway, Phillips, Owen and Moore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Craig S. Moore, email@example.com
†These authors have contributed equally to this work