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Front. Immunol. | doi: 10.3389/fimmu.2019.01722

Vaccine evolution and its application to fight modern threats

  • 1GlaxoSmithKline (Italy), Italy

Before the development of the first vaccine, infectious diseases were the major cause of deaths around the globe with life expectancy estimated to be less than 50 years. Three measures have helped to drastically reduced the burden of infectious diseases but only vaccines have proven to be able to eradicate infectious agents. Herein we describe new methodologies that have paved the way for what is currently conceived as modern vaccinology and the use of vaccines to tackle antimicrobial resistance, the biggest global threat of our days.

Keywords: Vaccines, infectious diseases, Antimicrobial resistance (AMR), vaccine development, vaccinology

Received: 08 May 2019; Accepted: 09 Jul 2019.

Edited by:

Ennio Carbone, Università degli studi Magna Græcia di Catanzaro, Italy

Reviewed by:

Sven Hammerschmidt, University of Greifswald, Germany
Paola Italiani, Italian National Research Council (CNR), Italy  

Copyright: © 2019 Andreano, D'Oro, Rappuoli and Finco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Oretta Finco, GlaxoSmithKline (Italy), Siena, 53100, Tuscany, Italy, oretta.x.finco@gsk.com