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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.01746

Role of Regulatory Immune Cells and Molecules in Autoimmune Bullous Dermatoses

 Tianyu Cao1, Shuai Shao2, Hui Fang2, Bing Li2 and  Gang Wang2*
  • 1Department of Dermatology, Tangdu Hospital, Fourth Military Medical University, China
  • 2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, China

Autoimmune bullous dermatoses (AIBD) include a series of typical organ-specific autoimmune diseases characterized by extensive mucocutaneous blisters. It is generally accepted to be caused by pathological autoantibodies that directly target specific adhesion components of the skin or the adjacent mucous membranes. Both innate and adaptive immune systems are critically involved in the misguided immune response against self-antigens. Recent studies have indicated that the dysfunction of regulatory T cells, regulatory B cells, and complement regulatory proteins that play essential roles in maintaining a healthy immune environment is also closely related to immune disorders in AIBD. It is important to summarize these studies, elucidate the changes in these regulatory immune cells and molecules for the pathogenesis of AIBD, and reveal the mechanisms by which they lose their ability to regulate immune disorders. In this review, we highlight the role of regulatory immune cells and molecules in the pathogenesis of pemphigus vulgaris and bullous pemphigoid, the two most representative forms of AIBD, and indicate issues that should be addressed in future investigations.

Keywords: Regulatory T cells (T reg), Regulatory B cells (Breg), Complement regulating proteins, Pemphigus Vulgaris (PV), Bullous pemphigoid (BP)

Received: 31 Mar 2019; Accepted: 10 Jul 2019.

Edited by:

Michele M. Kosiewicz, University of Louisville, United States

Reviewed by:

Maria I. Bokarewa, University of Gothenburg, Sweden
Åsa Andersson, Halmstad University, Sweden, Sweden  

Copyright: © 2019 Cao, Shao, Fang, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Gang Wang, Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, xjwgang@fmmu.edu.cn