The WNT framework in shaping immune cell responses during bacterial infections
- 1Indian Institute of Science (IISc), India
A large proportion of the world is inflicted with health concerns arising from infectious diseases. Moreover, there is a widespread emergence of antibiotic resistance among major infectious agents, partially stemming from their continuous dialog with the host and their enormous capacity to remodel the latter towards a secure niche. Among the several infection-driven events, moderation of WNT signaling pathway has been identified to be strategically tuned during infections to govern host-pathogen interactions. Primarily known for its role in arbitrating early embryonic developmental events; aberrant activation of the WNT pathway has also been associated with immunological consequences during diverse patho-physiological conditions. Here, we review the different mechanisms by which components of WNT signaling pathway are exploited by discrete bacterial agents for their pathogenesis. Furthermore, recent advances on the cross-talk of WNT with other signaling pathways, the varied modes of WNT-mediated alteration of gene expression; and WNT-dependent post-transcriptional and post-translational regulation of the immune landscape during distinct bacterial infections would be highlighted.
Keywords: Wnt, infectious diseases, epigenetics, nuclear Wnt signaling, Therapeutics
Received: 06 Jun 2019;
Accepted: 06 Aug 2019.
Edited by:Malini Sen, Indian Institute of Chemical Biology (CSIR), India
Reviewed by:Catherine A. Brissette, University of North Dakota, United States
Sahana Holla, National Cancer Institute (NCI), United States
Copyright: © 2019 Mukherjee and Balaji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Kithiganahalli N. Balaji, Indian Institute of Science (IISc), Bangalore, India, firstname.lastname@example.org