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Front. Immunol. | doi: 10.3389/fimmu.2019.02031

Emerging Roles For G-protein Coupled Receptors in Development and Activation of Macrophages: An update!

  • 1First Affiliated Hospital of Anhui Medical University, China
  • 2Anhui Medical University, China
  • 3Institute for Molecular Bioscience, University of Queensland, Australia
  • 4University of Tasmania, Australia
  • 5Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Australia

Macrophages have emerged as a key component of the innate immune system that emigrate to peripheral tissues during gestation and in the adult organism. Their complex pathway to maturity, their unique plasiticity and their various roles as effector and regulatory cells during an immue response have been the focus of intense research. A class of surface molecules, the G-Protein coupled receptors (GPCRs) play important roles in many immune processes. They have drawn attention in regard to these functions and the potential for therapeutic targets that can modulate the reponse of immune cells in pathologies such as diabetes, artherosclerosis and chronic inflammatory diseases. Of the more than 800 GPCRs identified, approximately 100 are currently targeted with drugs which have had their activity investigated in vivo. Macrophages express a number of GPCRs which have central roles during cell differentiation and in the regulation of their functions. While some macrophage GPCRs such as chemokine receptors have been studied in great detail, the roles of other receptors of this large family are still not well understood. This review summarizes new insights into macrophage biology, differences of human and mouse macrophages and gives details of some of the GPCRs expressed by this cell type.of the GPCR expressed by this cell type.

Keywords: G-protein coupled receptors, Macrophages, differentiation, polarization, innate immunity

Received: 06 Mar 2019; Accepted: 12 Aug 2019.

Edited by:

Jagadeesh BAYRY, Institut National de la Santé et de la Recherche Médicale (INSERM), France

Reviewed by:

Anastasios Lymperopoulos, Nova Southeastern University, United States
Klaus Scholich, University Hospital Frankfurt, Germany  

Copyright: © 2019 Wang, Iyer, Lyons, Korner and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Wei Wei, Anhui Medical University, Hefei, China, wwei@ahmu.edu.cn