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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02035

Human monocyte subsets and phenotypes in major chronic inflammatory diseases

 Theodore S. Kapellos1*, Lorenzo Bonaguro1, Ioanna Gemünd1, Nico Reusch1, Adem Saglam2, Emily R. Hinkley2 and  Joachim L. Schultze1, 2*
  • 1University of Bonn, Germany
  • 2German Center for Neurodegenerative Diseases (DZNE), Germany

Human monocytes are divided in three major populations; classical (CD14+CD16-), non-classical (CD14dimCD16+) and intermediate (CD14+CD16+). Each of these subsets is distinguished from each other by the expression of distinct surface markers and by their functions in homeostasis and disease. In this review, we discuss the most up-to-date phenotypic classification of human monocytes that has been greatly aided by the application of novel single-cell transcriptomic and mass cytometry technologies. Furthermore, we shed light on the role of these plastic immune cells in already recognized and emerging human chronic diseases, such as obesity, atherosclerosis, chronic obstructive pulmonary disease, lung fibrosis, lung cancer and Alzheimer’s disease. Our aim is to provide an insight into the contribution of human monocytes to the progression of these diseases and highlight their candidacy as potential therapeutic cell targets.

Keywords: human monocytes, Atherosclerosis, Diet, Respiratory diseases, neurodegeneration

Received: 01 Jul 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Kapellos, Bonaguro, Gemünd, Reusch, Saglam, Hinkley and Schultze. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Theodore S. Kapellos, University of Bonn, Bonn, Germany, tkapello@uni-bonn.de
Prof. Joachim L. Schultze, University of Bonn, Bonn, Germany, j.schultze@uni-bonn.de