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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02148

Disruption of neutrophil extracellular traps (NETs) links mechanical strain to post-traumatic inflammation

 Shailesh Agarwal1, Shawn Loder1,  David Cholok1, John Li1, Guowu Bian1, Shuli Li1, William Carson1, Matthew Delano1,  Theodore J. Standiford1, Steven Kunkel1,  Yuji Mishina1, Peter Ward1 and  Benjamin Levi2*
  • 1Michigan Medicine, University of Michigan, United States
  • 2University of Michigan, United States

Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound's response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.

Keywords: Mechanical Stress, Wound Healing, Trauma, Neutrophil, Neutrophils (PMNs)

Received: 23 Jan 2019; Accepted: 27 Aug 2019.

Copyright: © 2019 Agarwal, Loder, Cholok, Li, Bian, Li, Carson, Delano, Standiford, Kunkel, Mishina, Ward and Levi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Benjamin Levi, University of Michigan, Ann Arbor, United States, benlevimd@gmail.com