Targeting T cell metabolism in inflammatory skin disease
- 1Department of Dermatology, Inselspital, Bern University Hospital, Switzerland
- 2Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Germany
A properly functioning T cell compartment is crucial to protect the host from infections, tumors and environmental substances. In recent years, it has become increasingly clear that the processes underlying proper T cell activation, proliferation, and differentiation require well-tuned and dynamic changes in T cell metabolism. Thus, proper metabolic reprogramming in T cells is crucial to ensure proper immunity in the context of infection and anti-tumor immunity. Conversely, aberrant regulation of T cell metabolism can impair T cell function and thereby contribute to T cell-mediated disease. In this review, the relevance of recent insights into T cell metabolism for prototypical T cell-mediated skin diseases will be discussed and their therapeutic potential will be outlined. First, the major modules of T cell metabolism are summarized. Then, the importance of T cell metabolism for T cell-mediated skin diseases such as psoriasis and allergic contact dermatitis is discussed, based on the current state of our understanding thereof. Finally, novel therapeutic opportunities for inflammatory skin disease that might emerge from investigations in T cell metabolism are outlined.
Keywords: T cell metabolism, Inflammatory skin disease, Glycolysis, OxPhos, Lipid Metabolism
Received: 31 May 2019;
Accepted: 10 Sep 2019.
Copyright: © 2019 von Meyenn, Bertschi and Schlapbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Christoph Schlapbach, Bern University Hospital, Department of Dermatology, Inselspital, Bern, 3010, Bern, Switzerland, Christoph.Schlapbach@insel.ch