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Correction ARTICLE

Front. Immunol., 18 October 2019 | https://doi.org/10.3389/fimmu.2019.02409

Corrigendum: EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity

  • Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India

A Corrigendum on
EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity

by Asad, M., Sabur, A., Shadab, M., Das, S., Kamran, M., Didwania, N., et al. (2019). Front. Immunol. 10:616. doi: 10.3389/fimmu.2019.00616

In the original article, there was an error. “EBI-3” was misspelled as “EB1-3” in the title of the manuscript, supplementary material, and in the citation.

A correction has been made to the Title:

“EBI-3 chain of IL-35 along with TGF-β synergistically regulate anti-leishmanial immunity”

Additionally, “EBI-3 and p35 chains of IL-35” was mistakenly referred to as “EBI-3 and p35 chains of EBI-3.”

A correction has been made to the Abstract:

“Immunosuppression is a characteristic feature of chronic leishmaniasis. The dynamicity and the functional cross talks of host immune responses during Leishmania infection are still not clearly understood. Here we explored the functional aspects of accumulation of immune suppressive cellular and cytokine milieu during the progression of murine visceral leishmaniasis. In addition to IL-10 and TGF-β, investigation on the responses of different subunit chains of IL-12 family revealed a progressive elevation of EBI-3 and p35 chains of IL-35 with Leishmania donovani infection in BALB/c mice. The expansion of CD25 and FoxP3 positive T cells is associated with loss of IFN-γ and TNF-α response in advanced disease. Ex-vivo and in vivo neutralization of TGF-β and EBI-3 suggests a synergism in suppression of host anti-leishmanial immunity. The down-regulation of EBI-3 and TGF-β is crucial for re-activation of JAK-STAT pathway for induction as well as restoration of protective immunity against L. donovani infection.”

The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: regulatory T cells, Leishmania, immune response, interleukin-35, transforming growth factor beta, immune suppression

Citation: Asad M, Sabur A, Shadab M, Das S, Kamran M, Didwania N and Ali N (2019) Corrigendum: EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity. Front. Immunol. 10:2409. doi: 10.3389/fimmu.2019.02409

Received: 30 July 2019; Accepted: 26 September 2019;
Published: 18 October 2019.

Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2019 Asad, Sabur, Shadab, Das, Kamran, Didwania and Ali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Nahid Ali, nali@iicb.res.in

Present address: Mohammad Asad, School of Medicine, Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States
Mohammad Shadab, Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY, United States