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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02441

Potential role of gut microbiota in induction and regulation of innate immune memory

  • 1Institute of Microbial Technology (CSIR), India
  • 2Indian Institute of Technology Ropar, India

The gut microbiota significantly regulates the development and function of innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity. Recent evidence indicate that memory is also present in the innate immune cells such as monocytes/macrophages, and natural killer cells. These cells exhibit pattern recognition receptors (PRRs) that recognize microbe- or pathogen-associated molecular patterns (MAMPs or PAMPs) expressed by the microbes. Interaction between PRR and MAMP is quite crucial since it triggers the sequence of signaling events and epigenetic rewiring that play a cardinal role in modulating not only the activation and function of the innate cells but as well as imparts a sense of memory response. We discuss here how gut microbiota can influence the generation of innate memory and functional reprogramming of bone marrow progenitors that helps in protection against infections. This article will broaden our current perspective of association between the gut microbiome and innate memory. In future, this knowledge may pave avenues for development and designing of novel immunotherapies and vaccination strategies.

Keywords: Gut Microbiota, Macrophages, innate immunity, Innate memory, Monocytes

Received: 25 Jun 2019; Accepted: 01 Oct 2019.

Copyright: © 2019 Negi, Das, Pahari, Nadeem and Agrewala. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Javed N. Agrewala, Institute of Microbial Technology (CSIR), Chandigarh, 160036, Punjab, India,