Corrigendum: The TNF Paradox in Cancer Progression and Immunotherapy
- 1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France
- 2Université Toulouse III - Paul Sabatier, Toulouse, France
- 3Laboratoire de Biochimie, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France
- 4Dermatologie, Institut Universitaire du Cancer (IUCT-O) et CHU de Toulouse, Toulouse, France
A Corrigendum on
The TNF Paradox in Cancer Progression and Immunotherapy
by Montfort, A., Colacios, C., Levade, T., Andrieu-Abadie, N., Meyer, N., and Ségui, B. (2019). Front. Immunol. 10:1818. doi: 10.3389/fimmu.2019.01818
In the original article, there was an error. We stated that Infliximab is “a first-generation humanized TNF blocking antibody,” instead of “a first-generation chimeric TNF blocking antibody.”
A correction has been made to the section Combining TNF Blockade to Immune Checkpoint Blockers to Treat Melanoma, paragraph one:
“Although melanomas represent only 1% of all skin cancers, they are responsible for the majority of skin cancer deaths. The use of immune checkpoint inhibitors (ICI) considerably improved the prognosis for metastatic melanoma patients with an overall survival of 58% at 3 years when treated with a combination of anti-PD-1 (Nivolumab), and anti-CTLA4 (Ipilimumab) (30). However, median progression-free survival is still only 11.5 months with nearly all patients experiencing mild to severe (grade 3/4) immune-related adverse events (irAE) (Figure 1). Interestingly, Infliximab, a first-generation chimeric TNF blocking antibody is currently being used in the clinic to treat some of the irAEs, mainly colitis, sometimes triggered by ICI (31). The impact anti-TNF antibodies have on anti-cancer immune responses in these settings are not known. A recent study indicates that 1% of patients with advanced melanoma treated by ICI develop severe colitis, which can be efficiently cured with one infliximab infusion in most of the patients, without affecting disease outcome (32). A clinical study evaluating the tolerability of infliximab in advanced cancer patients shows no dose-limiting toxic (DLT) effects and no evidence of disease acceleration in any patient. Moreover, 7 out of 41 patients experienced disease stabilization, including 1 metastatic melanoma patient (33). Other studies indicate the safety and tolerability of administering anti-TNF (etanercept or infliximab) in cancer patients affected with ovarian cancer (34), or renal cell carcinoma (35).”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: tumor necrosis factor (TNF), PD-1, CTLA-4, melanoma, immune escape
Citation: Montfort A, Colacios C, Levade T, Andrieu-Abadie N, Meyer N and Ségui B (2019) Corrigendum: The TNF Paradox in Cancer Progression and Immunotherapy. Front. Immunol. 10:2515. doi: 10.3389/fimmu.2019.02515
Received: 07 October 2019; Accepted: 08 October 2019;
Published: 22 October 2019.
Approved by:Frontiers Editorial Office, Frontiers Media SA, Switzerland
Copyright © 2019 Montfort, Colacios, Levade, Andrieu-Abadie, Meyer and Ségui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bruno Ségui, firstname.lastname@example.org