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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02516

Granulocyte colony-stimulating factor primed unmanipulated haploidentical blood and marrow transplantation

 Ying-Jun Chang1, Xiang-Yu Zhao1 and  Xiao-Jun Huang1*
  • 1Peking University People's Hospital, China

Granulocyte colony-stimulating factor (G-CSF), a growth factor for neutrophils, has been successfully used for stem cell mobilization and T cell immune tolerance induction. The establishment of G-CSF-primed unmanipulated haploidentical blood and marrow transplantation (The Beijing Protocol) has achieved outcomes for the treatment of acute leukaemia, myelodysplastic syndrome, and severe aplastic anaemia with haploidentical allografts comparable to those of human leukocyte antigen (HLA)-matched sibling donor transplantation. Currently, G-CSF-mobilized bone marrow and/or peripheral blood stem cell sources have been widely used in unmanipulated haploidentical transplant settings. In this review, we summarize the roles of G-CSF in inducing T cell immune tolerance. We discuss the recent advances in the Beijing Protocol, mainly focusing on strategies that have been used to improve transplant outcomes in cases of poor graft function, virus infections, and relapse. The application of G-CSF-primed allografts in other haploidentical modalities is also discussed.

Keywords: Haploidentical stem cell transplantation, Granulocyte Colony-Stimulating Factor, poor graft function, relapse, Virus infections

Received: 31 May 2019; Accepted: 09 Oct 2019.

Copyright: © 2019 Chang, Zhao and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xiao-Jun Huang, Peking University People's Hospital, Beijing, China, huangxiaojun@bjmu.edu.cn