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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02523

Deciphering the role played by autophagy in Leishmania infection

  • 1Gonçalo Moniz Institute (IGM), Brazil
  • 2National Institute of Science and Technology of Tropical Diseases (INCT-DT), Brazil

In recent decades, studies have shown that, depending on parasite species and host background, autophagy can either favor infection or promote parasite clearance. To date, relatively few studies have attempted to assess the role played by autophagy in Leishmania infection. While it has been consistently shown that Leishmania spp. induce autophagy in a variety of cell types, published results regarding the effects of autophagic modulation on Leishmania survival are contradictory. The present review, after a short overview of the general aspects of autophagy, aims to summarize the current body of knowledge surrounding how Leishmania spp. adaptively interact with macrophages, the host cells mainly involved in controlling leishmaniasis. We then explore the scarce studies that have investigated interactions between these parasite species and the autophagic pathway, and finally present a critical perspective on how autophagy influences infection outcome.

Keywords: Autophagy, Leishmania, LC3, Macrophages, Phagocytosis, Leishmaniasis, Parasitophorous vacuoles

Received: 16 May 2019; Accepted: 10 Oct 2019.

Copyright: © 2019 Veras, De Menezes and Dias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Patricia S. Veras, Gonçalo Moniz Institute (IGM), Salvador, Brazil, pstveras@gmail.com