Impact Factor 7.561 | CiteScore 8.1
More on impact ›

EDITORIAL article

Front. Immunol., 20 December 2019 | https://doi.org/10.3389/fimmu.2019.02974

Editorial: Evolving Mechanisms of Disease Tolerance

  • 1Meakins-Christie Laboratories, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada
  • 2Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada
  • 3McGill International TB Centre, McGill University Health Centre, Montreal, QC, Canada

Editorial on the Research Topic
Evolving Mechanisms of Disease Tolerance

Within the last 150 years, morbidity and mortality due to infectious diseases has drastically decreased worldwide (1). This change in health began with the pioneering cowpox studies of Edward Jenner followed by Pasteur's germ theory and Koch's postulates that eventually led to improved hygiene strategies, the advent of vaccines and discovery of antibiotics (2). These seminal observations about the infectious origins of disease spawned the golden age of Immunology in which investigators such as Elie Metchnikoff and Paul Ehrlich broadly described the cellular and molecular mechanisms of host defense. However, it has now become clear that defense against infection extends beyond host resistance and also includes mechanisms that limit tissue damage independent of changes to pathogen burden (3). This latter strategy is referred to as disease tolerance and involves coordination between immune cells and tissue-specific structural cells to maximize host fitness in the face of disruption to homeostatic conditions (4). It is important that “disease tolerance” is not confused with the equally important concept of “immune tolerance” in which immune reactivity is inhibited by clonal deletion or silencing of antigen-specific lymphocytes (5). However, the possibility that immune tolerance and disease tolerance can operate in a complementary fashion within the same setting of infection or inflammation is certainly not excluded.

The concept of disease tolerance was introduced in 1894 by Nathan Augustus Cobb, an American plant pathologist. From his studies in wheat, he observed the ability of certain strains to yield crop despite the presence of a fungal infection or “rust.” He referred to this phenomenon as “rust-enduring” and distinguished this phenotype from “rust-resistant” wheat (6). Following Cobb's seminal observations, plant biologists rebranded the concept of endurance to disease tolerance (7). Although this concept was well-established in plant biology, it was not directly tested in mammals until more than a century later by Lars Råberg and Andrew Read. Specifically, they demonstrated that genetic variation in mice can delineate host resistance vs. disease tolerance following malaria infection (8). Soon after, molecular insights into these observations were provided by Miguel Soares' group demonstrating that tissue protection from the cytotoxic effects of malaria-induced hemolysis in mice is provided by the heme-catabolizing enzyme heme oxygenase-1 (9). In the same year, Ayres and Schneider demonstrated that simple organisms such as the fruit fly Drosophila melanogaster can also use disease tolerance as a host defense mechanism in the context of gram-positive and gram-negative bacterial infections (10, 11). Collectively, these studies have provided the impetus for investigating disease tolerance as an alternative and/or complementary form of host defense not only in the context of infection but also in settings of non-communicable diseases such as autoimmunity, asthma, and atherosclerosis.

This Frontiers Research Topic entitled “Evolving mechanisms of disease tolerance” aims to demonstrate how the research and our understanding of this concept is leading to, what we consider, a new golden age of infectious disease research and discovery. Considering the relevance of disease tolerance across the kingdoms of life and throughout the evolution of mammals, we have assembled exciting reviews detailing how this defense strategy is conserved from plants to humans against diverse forms of infection. Paudel and Sanfaçon return to the roots of disease tolerance by describing the mechanisms by which plants tolerate viral infection. Budischak and Cressler provide an ecological perspective on how environmental resources contribute to disease tolerance across the evolutionary spectrum. This study dovetails with the reviews of Carlos et al. whom discuss the impact of nutrient metabolism such as iron and glucose on tolerance to diverse pathogen challenge and Harbeson et al. whom examine how early-life metabolic responses impact long-term human health outcomes. Importantly, prokaryotes also utilize disease tolerance to defend against viral (i.e., bacteriophage) infection. Attention is brought to this emerging research field by Chatterjee and Duerkop highlighting the impact of bacteria-phage interactions and how they may contribute to eukaryotic immune responses.

Emphasizing the importance of disease tolerance during respiratory infection, Divangahi et al., Saelens et al., and Olive and Sassetti take aim at Mycobacterium tuberculosis. Their reviews emphasize how understanding the mechanisms of disease tolerance to Mtb infection may lead to new therapeutic strategies against Tuberculosis, the world's leading infectious killer. Beyond TB, extracellular bacterial and fungal infections of the lung remain important clinical problems, particularly in immunocompromised individuals. Disease tolerance to these pathogens are emphasized by Shourian and Qureshi in their discussion of Cryptococcus neoformans infection and Faure et al. whom describe mechanisms of host adaptation to Pseudomonas aeruginosa infection and how this response goes awry in patients with cystic fibrosis. Additionally, Allard et al. dedicate an entire article solely to describing how alveolar macrophages regulate disease tolerance in a range of settings from infection to allergy. In a complementary review, Crane et al. discuss the complex scenario in which primary respiratory viral infections can either increase or decrease disease tolerance to secondary bacterial infection depending on the immune status of the host. One important factor in the co-infection scenario are type 1 and type 2 interferons. These cytokines, reviewed by Lee and Ashkar, are rapidly and abundantly produced in response to viral and bacterial infection and have diverse roles in protective and pathogenic immune responses. In addition to highly replicative unicellular pathogens, hosts likely use distinct mechanisms of disease tolerance to protect against non-replicating, multicellular parasites. This form of pathogen challenge is the focus of two reviews in this Research Topic focusing on parasitic worm infection. Specifically, King and Li focus on the diverse mechanisms by which the mammalian host uses disease tolerance to defend as chronic intestinal helminth infection and, in a related article, Yap and Gause explore how helminths shape organ-specific strategies of disease tolerance and the consequences on heterologous infection. Finally, we have included a review by Mandl et al. in which they discuss how diverse species of bats are uniquely tolerant to viruses that are highly pathogenic to humans. Understanding the immune system of this animal will not only provide insight into mammalian mechanisms of disease tolerance, but also inform strategies that limit infection of this important pathogen reservoir. In sum, we hope that this collection will highlight recent developments related to the origins and function of disease tolerance as well as persuade the development of therapeutic strategies targeting this fundamental strategy of host defense against infectious diseases.

Author Contributions

IK and MD contributed equally to this editorial and have approved it for publication.

Funding

This work was supported by a CIHR operating grant (MOP-130579) to IK, a CIHR Foundation Grant (FDN-143273) to MD, the generous support of J. T. Costello Memorial Research Fund, the Richard and Edith Strauss Canada Foundation and the LIoyd Carr-Harris Foundation. IK was a Canada Research Chair in Barrier Immunity and MD holds a Strauss Chair in Respiratory Diseases.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

1. World Bank. (2019). Available online at: https://data.worldbank.org/indicator/sp.dyn.cdrt.in

Google Scholar

2. Lederberg J. Infectious history. Science. (2000) 288:287–93. doi: 10.1126/science.288.5464.287

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Soares MP, Teixeira L, Moita LF. Disease tolerance and immunity in host protection against infection. Nat Rev Immunol. (2017) 17:83–96. doi: 10.1038/nri.2016.136

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Medzhitov R, Schneider DS, Soares MP. Disease tolerance as a defense strategy. Science. (2012) 335:936–41. doi: 10.1126/science.1214935

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Xing Y, Hogquist KA. T-cell tolerance: central and peripheral. Cold Spring Harb Perspect Biol. (2012) 4:a006957. doi: 10.1101/cshperspect.a006957

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Cobb NA. Contributions to an Economic Knowledge of Australian Rusts (Uredineae): Improving Wheat by Selection. Sydney, NSW: C. Potter; Dep. Agric. (1894).

Google Scholar

7. Caldwell RM, Schafer JF, Compton LE, Patterson FL. Tolerance to cereal leaf rusts. Science. (1958) 128:714–5. doi: 10.1126/science.128.3326.714

PubMed Abstract | CrossRef Full Text | Google Scholar

8. Raberg L, Sim D, Read AF. Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science. (2007) 318:812–4. doi: 10.1126/science.1148526

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Seixas E, Gozzelino R, Chora A, Ferreira A, Silva G, Larsen R, et al. Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci USA. (2009) 106:15837–42. doi: 10.1073/pnas.0903419106

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Ayres JS, Schneider DS. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol. (2008) 6:2764–73. doi: 10.1371/journal.pbio.0060305

PubMed Abstract | CrossRef Full Text | Google Scholar

11. Ayres JS, Freitag N, Schneider DS. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. (2008) 178:1807–15. doi: 10.1534/genetics.107.083782

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: host defense, infection, immunity, disease tolerance, tissue damage

Citation: King IL and Divangahi M (2019) Editorial: Evolving Mechanisms of Disease Tolerance. Front. Immunol. 10:2974. doi: 10.3389/fimmu.2019.02974

Received: 20 November 2019; Accepted: 04 December 2019;
Published: 20 December 2019.

Edited and reviewed by: Ian Marriott, University of North Carolina at Charlotte, United States

Copyright © 2019 King and Divangahi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Irah L. King, irah.king@mcgill.ca; Maziar Divangahi, maziar.divangahi@mcgill.ca