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Front. Immunol., 28 January 2021
Sec. Molecular Innate Immunity

Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways

  • 1Institute of Organic Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria
  • 2Research Group Innate Immunity, Research Center Borstel—Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Disease (DZL), Borstel, Germany

In the original article “Muzio, M., Ni, J., Feng, P., and Dixit, V.M. Science (1997) 278(5343):1612–1615” was not cited in the article.

The citation has now been inserted as reference “51” in section Lipopolysaccharide Detection by the Innate Immune System, subsection TLR4-Mediated Signaling Pathways, paragraph two, and should read:

“MyD88 is a 296 aa adaptor protein containing two major domains: a C-terminal TIR domain which associates with other TIR domain-containing proteins and a N-terminal death domain (DD) which mediates the interaction with the IRAK (IL-1R associated kinase) family kinases (49–51). Whereas recruitment to TLR4 is facilitated by homotypic TIR domain interactions and requires the bridging adaptor MAL (52, 53), DDs are used to engage members of the IRAK family to the complex. The whole complex comprises of 14-16 MyD88 and IRAK1, -2, and -4 molecules and has been termed the myddosome (54).”

All reference numbers have been updated accordingly.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: lipid A, inflammation, chemical structure, innate immunity, molecular recognition, TLR4/MD-2, inflammasome, aminoarabinose

Citation: Zamyatina A and Heine H (2021) Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways. Front. Immunol. 12:649442. doi: 10.3389/fimmu.2021.649442

Received: 04 January 2021; Accepted: 05 January 2021;
Published: 28 January 2021.

Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2021 Zamyatina and Heine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Alla Zamyatina,