Skip to main content

ORIGINAL RESEARCH article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1365430
This article is part of the Research Topic Crosstalk: Skin Cells and Immune Cells in Inflammatory Skin Diseases View all 16 articles

Impact of fucosyltransferase 1-mediated epidermal blood group antigen H on antiinflammatory response in atopic dermatitis

Provisionally accepted
Youngae Lee Youngae Lee *Na Li Na Li Jang-Hee Oh Jang-Hee Oh Joong Heon Suh Joong Heon Suh Seon-Pil Jin Seon-Pil Jin Dong Hun Lee Dong Hun Lee Jin Ho Chung Jin Ho Chung *
  • College of Medicine, Seoul National University, Seoul, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    The presence of the blood group H2 antigen on the membrane of red blood cells determines blood type O in individuals and this H2 antigen serves as a precursor to the A and B antigens expressed in blood types A and B, respectively. However, the specific involvement of ABH antigens in skin diseases is unknown. Therefore, we aim to investigate the expression of ABH antigens in skin tissue of patients with atopic dermatitis (AD) and MC903-induced AD-like mice. We demonstrated that the expression of ABH antigen is primarily located in the granular and horny layers of the skin in healthy control individuals. However, in patients with AD, the expression of the ABH antigen was absent or diminished in these layers, while the H2 antigen expression increased in the spinous layers of the affected skin lesions. Then, we investigated the biological function of blood group H antigen mediated by fucosyltransferase 1 (Fut1) in the skin, utilizing an AD mouse model induced by MC903 in wild-type (WT) and Fut1-knockout mice. After the application of MC903, Fut1-deficient mice, with no H2 antigen expression on their skin, exhibited more severe clinical signs, increased ear swelling, and elevated serum IgE levels compared with those of WT mice. Additionally, the MC903-induced thickening of both the epidermis and dermis was more pronounced in Fut1-deficient mice than that in WT mice. Furthermore, Fut1-deficient mice showed a significantly higher production of interleukin-4 (IL-4) and IL-6 in skin lesions compared with that of their WT counterparts.The expression of chemokines, particularly Ccl2 and Ccl8, was notably higher in Fut1deficient mice compared with those of WT mice. The infiltration of CD4 + T cells, eosinophils, and mast cells into the lesional skin was significantly elevated in Fut1deficient mice compared with that in WT mice. These findings the protective role of H2 antigen expression against AD-like inflammation and highlight its potential therapeutic impact on AD through the regulation of blood group antigens.

    Keywords: ABH antigens, Fucosyltransferase 1, atopic dermatitis, Cytokines, Chemokines

    Received: 04 Jan 2024; Accepted: 07 May 2024.

    Copyright: © 2024 Lee, Li, Oh, Suh, Jin, Lee and Chung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Youngae Lee, College of Medicine, Seoul National University, Seoul, 03080, Seoul, Republic of Korea
    Jin Ho Chung, College of Medicine, Seoul National University, Seoul, 03080, Seoul, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.