%A Motloch,Lukas J. %A Jirak,Peter %A Gareeva,Diana %A Davtyan,Paruir %A Gumerov,Ruslan %A Lakman,Irina %A Tataurov,Aleksandr %A Zulkarneev,Rustem %A Kabirov,Ildar %A Cai,Benzhi %A Valeev,Bairas %A Pavlov,Valentin %A Kopp,Kristen %A Hoppe,Uta C. %A Lichtenauer,Michael %A Fiedler,Lukas %A Pistulli,Rudin %A Zagidullin,Naufal %D 2022 %J Frontiers in Medicine %C %F %G English %K COVID-19,long COVID-19,Post-discharge mortality,Cardiovascular biomarkers,SST2,VCAM-1 %Q %R 10.3389/fmed.2022.906665 %W %L %M %P %7 %8 2022-June-28 %9 Original Research %# %! Cardiovascular biomarkers for risk prediction in COVID-19. %* %< %T Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia %U https://www.frontiersin.org/articles/10.3389/fmed.2022.906665 %V 9 %0 JOURNAL ARTICLE %@ 2296-858X %X AimsWhile COVID-19 affects the cardiovascular system, the potential clinical impact of cardiovascular biomarkers on predicting outcomes in COVID-19 patients is still unknown. Therefore, to investigate this issue we analyzed the prognostic potential of cardiac biomarkers on in-hospital and long-term post-discharge mortality of patients with COVID-19 pneumonia.MethodsSerum soluble ST2, VCAM-1, and hs-TnI were evaluated upon admission in 280 consecutive patients hospitalized with COVID-19-associated pneumonia in a single, tertiary care center. Patient clinical and laboratory characteristics and the concentration of biomarkers were correlated with in-hospital [Hospital stay: 11 days (10; 14)] and post-discharge all-cause mortality at 1 year follow-up [FU: 354 days (342; 361)].Results11 patients died while hospitalized for COVID-19 (3.9%), and 11 patients died during the 1-year post-discharge follow-up period (n = 11, 4.1%). Using multivariate analysis, VCAM-1 was shown to predict mortality during the hospital period (HR 1.081, CI 95% 1.035;1.129, p = 0.017), but not ST2 or hs-TnI. In contrast, during one-year FU post hospital discharge, ST2 (HR 1.006, 95% CI 1.002;1.009, p < 0.001) and hs-TnI (HR 1.362, 95% CI 1.050;1.766, p = 0.024) predicted mortality, although not VCAM-1.ConclusionIn patients hospitalized with Covid-19 pneumonia, elevated levels of VCAM-1 at admission were associated with in-hospital mortality, while ST2 and hs-TnI might predict post-discharge mortality in long term follow-up.