%A Motloch,Lukas J.
%A Jirak,Peter
%A Gareeva,Diana
%A Davtyan,Paruir
%A Gumerov,Ruslan
%A Lakman,Irina
%A Tataurov,Aleksandr
%A Zulkarneev,Rustem
%A Kabirov,Ildar
%A Cai,Benzhi
%A Valeev,Bairas
%A Pavlov,Valentin
%A Kopp,Kristen
%A Hoppe,Uta C.
%A Lichtenauer,Michael
%A Fiedler,Lukas
%A Pistulli,Rudin
%A Zagidullin,Naufal
%D 2022
%J Frontiers in Medicine
%C
%F
%G English
%K COVID-19,long COVID-19,Post-discharge mortality,Cardiovascular biomarkers,SST2,VCAM-1
%Q
%R 10.3389/fmed.2022.906665
%W
%L
%M
%P
%7
%8 2022-June-28
%9 Original Research
%#
%! Cardiovascular biomarkers for risk prediction in COVID-19.
%*
%<
%T Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia
%U https://www.frontiersin.org/articles/10.3389/fmed.2022.906665
%V 9
%0 JOURNAL ARTICLE
%@ 2296-858X
%X AimsWhile COVID-19 affects the cardiovascular system, the potential clinical impact of cardiovascular biomarkers on predicting outcomes in COVID-19 patients is still unknown. Therefore, to investigate this issue we analyzed the prognostic potential of cardiac biomarkers on in-hospital and long-term post-discharge mortality of patients with COVID-19 pneumonia.MethodsSerum soluble ST2, VCAM-1, and hs-TnI were evaluated upon admission in 280 consecutive patients hospitalized with COVID-19-associated pneumonia in a single, tertiary care center. Patient clinical and laboratory characteristics and the concentration of biomarkers were correlated with in-hospital [Hospital stay: 11 days (10; 14)] and post-discharge all-cause mortality at 1 year follow-up [FU: 354 days (342; 361)].Results11 patients died while hospitalized for COVID-19 (3.9%), and 11 patients died during the 1-year post-discharge follow-up period (n = 11, 4.1%). Using multivariate analysis, VCAM-1 was shown to predict mortality during the hospital period (HR 1.081, CI 95% 1.035;1.129, p = 0.017), but not ST2 or hs-TnI. In contrast, during one-year FU post hospital discharge, ST2 (HR 1.006, 95% CI 1.002;1.009, p < 0.001) and hs-TnI (HR 1.362, 95% CI 1.050;1.766, p = 0.024) predicted mortality, although not VCAM-1.ConclusionIn patients hospitalized with Covid-19 pneumonia, elevated levels of VCAM-1 at admission were associated with in-hospital mortality, while ST2 and hs-TnI might predict post-discharge mortality in long term follow-up.