Impact Factor 4.019

The world's most-cited Microbiology journal

This article is part of the Research Topic

Zika Virus Research

General Commentary ARTICLE

Front. Microbiol., 07 September 2016 | https://doi.org/10.3389/fmicb.2016.01398

Response: Commentary: Zika Virus: the Latest Newcomer

  • Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain

A commentary on
Commentary: Zika Virus: the Latest Newcomer

by Craig, A. T., Paterson, B. J., and Durrheim, D. N. (2016). Front. Microbiol. 7:1028. doi: 10.3389/fmicb.2016.01028

We really appreciate Craig et al. (2016) for their commended to our contribution to the current knowledge about Zika Virus (ZIKV), and their comments to the possible relationship between Guillain-Barre syndrome (GBS) and ZIKV infection (Saiz et al., 2016). Even more, we absolutely agree with their interpretations and recommendations pointing to the necessity of further research to accurately quantify the effect of enhanced surveillance related to ZIKV circulation and associated risks. In fact, we clearly stated in the abstract of our review (Saiz et al., 2016) and throughout the text, including our final remarks, that clarifying whether there is a causal link between ZIKV infection and GBS is a currently unavoidable goal.

In this regard, recently, we have specifically addressed what it is currently known about ZIKV infections in relation with neurological manifestations (Blázquez and Saiz, in press), and stated that, beside the reported data pointing to a relationship between ZIKV infection and GBS, so far, a causal association has not been yet solidly established.

GBS is a clinical syndrome of multiple autoimmune etiologies and the most common and severe acute paralytic neuropathy (van den Berg et al., 2014; Willison et al., 2016). In in many cases GBS appears to be associated with antecedent infectious diseases (Winner, 2001), and sporadic arboviral infections with dengue virus, DENV (Garg et al., 2015; Simon et al., 2016), West Nile virus, WNV (Sejvar, 2004), or chikungunya virus, CHIKV (Wielanek et al., 2007) have already been associated to GBS. In fact, Malone et al. (2016) have suggested that the concomitant regional increase in DENV and CHIKV infections may have contribute to the recently registered increase in GBS incidence.

In any case, and beyond the considerable efforts carried out by the scientific community and the national and international health authorities focused on deciphering ZIKV infection and its consequences, sufficient resources should be allocated to provide the necessary tools to evaluate the potential mechanisms of ZIKV association to GBS.

Author Contributions

All authors conceived the ideas presented in the article. J-CS led the drafting of the article with inputs from all other contributors. AV-C led the submission process.

Funding

This work was supported by grant ZIKA-BIO from INIA to J-CS, and AGL2014-56518-JIN from MINECO to MM, AV-C is a recipient of a “Contrato de formación postodoctoral” from MINECO. TM is a recipient of a “Formación de Personal Investigador (FPI)” pre-doctoral fellowship from INIA.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

Blázquez, A. B., and Saiz, J.-C. (in press). Neurological manifestations of Zika Virus infection. World J. Virol. Available online at: http://www.wjgnet.com/esps/ArticleInPressDetail.aspx?id=26415

PubMed Abstract

Craig, A. T., Paterson, B. J., and Durrheim, D. N. (2016). Commentary: Zika virus: the latest newcomer. Front. Microbiol. 7:1028. doi: 10.3389/fmicb.2016.01028

PubMed Abstract | CrossRef Full Text | Google Scholar

Garg, R. K., Malhotra, H. S., Jain, A., and Malhotra, K. P. (2015). Dengue-associated neuromuscular complications. Neurol. India 63, 497–516. doi: 10.4103/0028-3886.161990

PubMed Abstract | CrossRef Full Text | Google Scholar

Malone, R. W., Homan, J., Callahan, M. V., Glasspool-Malone, J., Damodaran, L., Schneider, A., et al. (2016). Zika virus: medical countermeasure development challenges. PLoS Negl. Trop Dis. 10:e0004530. doi: 10.1371/journal.pntd.0004530

PubMed Abstract | CrossRef Full Text | Google Scholar

Saiz, J.-C., Vázquez-Calvo, A., Blázquez, A. B., Merino-Ramos, T., Escribano-Romero, E., and Martín-Acebes, M. A. (2016). Zika virus: the latest newcomer. Front. Microbiol. 7:496. doi: 10.3389/fmicb.2016.00496

PubMed Abstract | CrossRef Full Text | Google Scholar

Sejvar, J. J. (2004). West Nile virus and “poliomyelitis”. Neurology 63, 206–207. doi: 10.1212/01.WNL.0000130361.62281.69

PubMed Abstract | CrossRef Full Text

Simon, O., Billot, S., Guyon, D., Daures, M., Descloux, E., Gourinat, A. C., et al. (2016). Early Guillain-Barre Syndrome associated with acute dengue fever. J. Clin. Virol. 77, 29–31. doi: 10.1016/j.jcv.2016.01.016

PubMed Abstract | CrossRef Full Text | Google Scholar

van den Berg, B., Walgaard, C., Drenthen, J., Fokke, C., Jacobs, B. C., and van Doorn, P. A. (2014). Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat. Rev. Neurol. 10, 469–482. doi: 10.1038/nrneurol.2014.121

PubMed Abstract | CrossRef Full Text | Google Scholar

Wielanek, A. C., Monredon, J. D., Amrani, M. E., Roger, J. C., and Serveaux, J. P. (2007). Guillain-Barre syndrome complicating a Chikungunya virus infection. Neurological 69, 2105–2107. doi: 10.1212/01.wnl.0000277267.07220.88

PubMed Abstract | CrossRef Full Text | Google Scholar

Willison, H. J., Jacobs, B. C., and van Doorn, P. A. (2016). Guillain-Barré syndrome. Lancet 388, 717–727. doi: 10.1016/S0140-6736(16)00339-1

PubMed Abstract | CrossRef Full Text | Google Scholar

Winner, J. B. (2001). Guillain Barré syndrome. Mol. Pathol. 54, 381–385. doi: 10.1016/j.transci.2016.01.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: Zika virus (ZIKV), Guillain-Barre syndrome, Flavivirus, surveillance, communicable diseases

Citation: Saiz J-C, Blázquez AB, De Oya NJ, Merino-Ramos T, Martín-Acebes MA, Escribano-Romero E and Vázquez-Calvo Á (2016) Response: Commentary: Zika Virus: the Latest Newcomer. Front. Microbiol. 7:1398. doi: 10.3389/fmicb.2016.01398

Received: 23 June 2016; Accepted: 24 August 2016;
Published: 07 September 2016.

Edited by:

Slobodan Paessler, University of Texas Medical Branch, USA

Reviewed by:

Jorg Heukelbach, Federal University of Ceará, Brazil
Yu Shin Kim, University of Texas Medical Branch, USA

Copyright © 2016 Saiz, Blázquez, De Oya, Merino-Ramos, Martín-Acebes, Escribano-Romero and Vázquez-Calvo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Juan-Carlos Saiz, jcsaiz@inia.es