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Front. Microbiol. | doi: 10.3389/fmicb.2018.02226

Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus

 Tianlong Liu1*, Jijin Tian1, Ruiwen Li2,  Ruiping She1, Jingyuan Wang1, Yue Yang1, Zhenning Sun1, Yingying Zhang1, Yifei Yang1, Xinxin Ren1, Yiyao Lu1 and Ruihan Shi1
  • 1China Agricultural University, China
  • 2School of Animal Medicine, Hebei Agricultural University, China

Recently, mechanism study of hepatitis E virus (HEV) infection has attracted an increasing attention because of the growing rate of the acute hepatitis caused by the virus over the world. As an important initiate in the inflammation, mast cells (MCs) play a critical role in maintaining a healthy physiology. However, the function of the MCs in the acute hepatitis caused by HEV is still unclear. In the present study, mongolian gerbils infected by HEV were used as an animal model to evaluate the role of MCs in the HEV infection. The positive ELISA and RT-PCR results showed the gerbils was successfully infected with HEV. The number of mast cell in the liver and the small intestine in the infected animals were grow higher significantly than the control group. In addition, higher expression of the tryptase and 5-HT in the liver and the intestine detected by immunohistochemical method and western blot also indicate the activation of mast cells in the infection. These results suggest that MCs play an important role in the hepatitis E.

Keywords: Mongolian gerbils, Hepatitis E virus, experimental infection, mast cell, activation

Received: 08 Feb 2018; Accepted: 31 Aug 2018.

Edited by:

Barry Rockx, RIVM, Netherlands

Reviewed by:

Larance Ronsard, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology, United States
Erin DiCaprio, University of California, Davis, United States  

Copyright: © 2018 Liu, Tian, Li, She, Wang, Yang, Sun, Zhang, Yang, Ren, Lu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: DVM, PhD. Tianlong Liu, China Agricultural University, Beijing, China, liutianlong@cau.edu.cn