Clever cooperation: Interactions between EspF and host proteins
- 1Department of Microbiology, School of Public Health, Southern Medical University, China
- 2Guangdong Provincial Key Laboratory of Tropical Diseases, Southern Medical University, China
EspF is a central effector protein of enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), and Citrobacter rodentium (CR) that is secreted through the type III secretion system to host cells. The interaction between EspF and host proteins plays an important role in bacterial pathogenesis. EspF protein binds to host SNX9 and N-WASP proteins to promote the colonization of pathogenic bacteria in intestinal epithelial cells; combines with cytokeratin 18, actin, 14-3-3ζ, Arp2/3, profilin, and ZO-1 proteins to intervene in the redistribution of intermediate filaments, the rearrangement of actin, and the disruption of tight junctions; acts together with Abcf2 to boost host cell intrinsic apoptosis; and collaborates with Anxa6 protein to inhibit phagocytosis. The interaction between EspF and host proteins is key to the pathogenic mechanism of EHEC and EPEC. Here, we review how EspF protein functions through interactions with these 10 host proteins and contributes to the pathogenicity of EHEC/EPEC.
Keywords: EPEC, EHEC (enterohaemorrhagic E. coli), EspF, protein interactions, Bacterial Pathogenesis
Received: 31 Aug 2018;
Accepted: 05 Nov 2018.
Edited by:Xihui Shen, Northwest A&F University, China
Reviewed by:Stephanie R. Shames, Kansas State University, United States
Christian Rueter, Universitätsklinikum Münster, Germany
Copyright: © 2018 Hua, Yan and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Chengsong Wan, Southern Medical University, Department of Microbiology, School of Public Health, Guangzhou, China, email@example.com