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Front. Microbiol. | doi: 10.3389/fmicb.2018.02898

Emergence and persistence of high-risk clones among MDR and XDR A. baumannii at a Brazilian teaching hospital

Lais C. Tavares1, 2,  Francielli M. Vasconcellos1, William V. Sousa1, Taisa T. Rocchetti3, Alessandro L. Mondelli3, Adriano M. Ferreira3, Augusto C. Montelli3, Terue Sadatsune4, Monique R. Tiba-Casas1 and  Carlos H. Camargo1*
  • 1Instituto Adolfo Lutz, Brazil
  • 2Faculty of Medicine, University of São Paulo, Brazil
  • 3Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Brazil
  • 4Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Brazil

Dissemination of carbapenem-resistant Acinetobacter baumannii is currently one of the priority themes discussed around the world, including in Brazil, where this pathogen is considered endemic. A total of 107 carbapenem-resistant A. baumannii (CRAB) isolates were collected from patients with bacteraemia attended at a teaching hospital in Brazil from 2008 to 2014. From these samples, 104 (97.2%) carried blaOXA-23-like, all of them associated with ISAba1 The blaOXA-231 (1.9%) and blaOXA-72 (0.9%) genes were also detected in low frequencies. All isolates were susceptible to minocycline, and 38.3% of isolates presented intermediate susceptibility to tigecycline (MIC = 4μg/ml). Molecular typing assessed by multi-locus sequence typing demonstrated that the strains were mainly associated with clonal complexes CC79 (47.4%), followed by CC1 (16.9%), and CC317 (18.6%), belonging to different pulsotypes and in different prevalences over the years. Changes in the clones’ prevalence reinforce the need of identifying and controlling CRAB in hospital settings to preserve the already scarce therapeutic options available.

Keywords: Acinetobacter baumannii, Oxacillinases, resistance epidemiology, Healthcare associated infection (HAI), Clonal complex (CC), MLST analysis

Received: 28 Jul 2018; Accepted: 12 Nov 2018.

Edited by:

Maria A. Mussi, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina

Reviewed by:

Benjamin A. Evans, University of East Anglia, United Kingdom
Guillermo D. Repizo, CONICET Instituto de Biología Molecular y Celular de Rosario (IBR), Argentina  

Copyright: © 2018 Tavares, Vasconcellos, Sousa, Rocchetti, Mondelli, Ferreira, Montelli, Sadatsune, Tiba-Casas and Camargo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Carlos H. Camargo, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil, chcamargo@ial.sp.gov.br