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Front. Microbiol. | doi: 10.3389/fmicb.2019.01187

Bacteriophage production models: an overview

  • 1Institute of Biology, Faculty of Sciences, Pontifical Catholic University of Valparaíso, Chile
  • 2Institute of Nutrition and Food Technology (INTA), Chile
  • 3Institute of Biomedical Sciences, University of Chile, Chile

The use of bacteriophages has been proposed as an alternative method to control pathogenic bacteria. During recent years several reports have been published about the successful use of bacteriophages in different fields such as food safety, agriculture, aquaculture and even human health. Several companies are now commercializing bacteriophages or bacteriophage-based products for therapeutic purposes. However, this technology is still in development and there are challenges to overcome before bacteriophages can be widely used to control pathogenic bacteria. One big hurdle is the development of efficient methods for bacteriophage production. To date, several models for bacteriophage production have been reported, some of them evaluated experimentally. This mini-review offers an overview of different models and methods for bacteriophage production, contrasting their principal differences.

Keywords: Bacteriophage, phage therapy, Bacteriophage therapy, phage production models, Bacteriophage production

Received: 16 Jan 2019; Accepted: 09 May 2019.

Edited by:

Robert Czajkowski, University of Gdansk, Poland

Reviewed by:

Konstantin A. Miroshnikov, Institute of Bioorganic Chemistry (RAS), Russia
Diana Gutiérrez, Institute of Dairy Products of Asturias (IPLA), Spain
Malgorzata B. Lobocka, Institute of Biochemistry and Biophysics (PAN), Poland  

Copyright: © 2019 García, Latz, Romero, Higuera, García and Bastías. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Roberto Bastías, Institute of Biology, Faculty of Sciences, Pontifical Catholic University of Valparaíso, Valparaiso, Chile, roberto.bastias@pucv.cl