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Front. Microbiol. | doi: 10.3389/fmicb.2019.01719

Regulation of respiratory pathways in Campylobacerota: a review

  • 1Infection & Immunology, Utrecht University, Netherlands
  • 2INSERM US01 Soutien a la recherche de l’institut europeen de chimie biologique, France

The Campylobacerota, previously known as Epsilonproteobacteria, are a large group of Gram-negative mainly, spiral-shaped motile bacteria. Some members like the Sulfurospirillum spp. are free-living, while others such as Helicobacter spp. can only persist in strict association with a host organism as commensal or as pathogen. Species of this phylum colonize diverse habitats ranging from deep-sea thermal vents to the human stomach wall. Despite their divergent environments, they share common energy conservation mechanisms. The Campylobacerota have a large and remarkable repertoire of electron transport chain enzymes, given their small genomes. Although members of recognized families of transcriptional regulators are found in these genomes, sofar no orthologs known to be important for energy or redox metabolism such as ArcA, FNR or NarP are encoded in the genomes of the Campylobacerota. In this review, we discuss the strategies that members of Campylobacerota utilize to conserve energy and the corresponding regulatory mechanisms that regulate the branched electron transport chains in these bacteria.

Keywords: Electron donor/acceptor, Electron metabolism, Campylobacter jejuni, Helicobacter pylori, Arcobacter butzleri, Sulfurimonas denitrificans, Sulfurospirillum multivorans, Wolinella succinogenes

Received: 12 Sep 2018; Accepted: 11 Jul 2019.

Edited by:

Martin G. Klotz, Washington State University, United States

Reviewed by:

James Hemp, California Institute of Technology, United States
Thomas E. Hanson, University of Delaware, United States  

Copyright: © 2019 Wosten and van der Stel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Marc M. Wosten, Utrecht University, Infection & Immunology, Utrecht, Netherlands,