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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Microbiol. | doi: 10.3389/fmicb.2019.01756

Origins and evolution of the of α-L-fucosidases: from bacteria to Metazoa

Jia You1 and  Tao Jiang1*
  • 1First Affiliated Hospital of Fujian Medical University, China

α-L-fucosidases (EC 3.2.1.51, FUC) belonging to glycoside hydrolase family 29 (GH29) play important roles in several biological processes and is recognized as a marker for detecting hepatocellular carcinoma. In this study, protein sequence similarity network (SSN) and evolutionary analysis were performed to understand the enzymes comprehensively. SSN indicated that the proteins in FUC family are mainly present in bacteria, fungi, Metazoa, and plants, but less in archaea. The sequences in bacteria are much diverse compared that in other taxonomic groups. SSN together with phylogenetic tree supported that the proteins in FUC family can be classified into 5 subfamilies. The multiple sequence alignments results indicated that the amino acid residues for binding α-L-fucosidase and catalysis are highly conserved in both bacteria and Metazoa, however, the evolutionary patterns were different based on the coevolution analysis. Because the enzymes from bacteria and Metazoa fall in the same subfamily, we proposed that the ancestral gene encoding α-L-fucosidase appeared before bacteria and eukaryotes diverged and bacterial and Metazoa α-L-fucosidases share a common ancestor. Finally, gene duplication plays an important role for α-L-fucosidase evolution not only in Metazoa but also in bacteria and fungi.

Keywords: α-L-fucosidase, evolution, Sequence similarity network, Bacteria, metazoa

Received: 16 Apr 2019; Accepted: 16 Jul 2019.

Copyright: © 2019 You and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Tao Jiang, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China, jiangtao2607@fjmu.edu.cn