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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Microbiol. | doi: 10.3389/fmicb.2019.02415

Crosstalk between gut microbiota and immune deficiency – an observation of dynamic microbial shift in immunodeficient mice

Shuyu Zheng1, 2, Tingting Zhao1, Shuijuan Yuan1,  Lingyu Yang1,  Jinmei Ding1 and  Li Cui1, 3*
  • 1Shanghai Jiao Tong University, China
  • 2School of Medicine, Shanghai Jiao Tong University, China
  • 3Shanghai Key Laboratory of Veterinary Biotechnology (ShKLVB), China

The crosstalk between gut microbiota and immune state of the host is an essential focus in academia and clinics. To explore the dynamic role of the microbiota in response to immune deficiency, we comprehensively assessed the microbiome of 90 mouse fecal samples, across 3 time points including two immunodeficiency models, namely severe combined immunodeficient (SCID) mice and non-obese diabetic SCID (NOD/SCID) mice, with BALB/c as a control strain. Metagenome analysis revealed a decrease in alpha diversity and a clear structural separation exist in the microbiota of immunodeficient mice. Although nuances exist between SCID and NOD/SCID mice, an increase in the protective microbiota, in particular Lactobacillus, contributed the most to the discrimination of immunodeficient and control mice. Further data regarding the RBC concentration and serum IgA level during different stages of development support the alleviation role of the microbiota in the progress of immune deficiency, which is called microbial compensation. Taken together, these results demonstrated a dynamic impact of immunodeficiency on gut microbiota and the adaptive alteration of microbiota that may influence the host state.

Keywords: Gut Microbiota, immunodeficiency, Metagenomics analysis, IgA, Dysbiosis

Received: 11 Jun 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Zheng, Zhao, Yuan, Yang, Ding and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Li Cui, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai Municipality, China, lcui@sjtu.edu.cn