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Front. Microbiol. | doi: 10.3389/fmicb.2019.02725

Development of Small-Molecule Inhibitors Against Zika Virus Infection

 Lili Wang1, Ruiying Liang1, Yaning Gao2, Yanbai Li1, Xiaoqian Deng1, Rong Xiang1, Yina Zhang1,  Tianlei Ying3*,  Shibo Jiang3* and  Fei Yu1*
  • 1Hebei Agricultural University, China
  • 2Peking University, China
  • 3Fudan University, China

In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a major threat to global public health, calling for the development of therapeutics to treat Zika virus disease. Here we described the different stages of the ZIKV life cycle and summarized the latest progress in the development of small-molecule inhibitors against ZIKV infection. We also discuss some general strategies for the discovery of small-molecule ZIKV inhibitors.

Keywords: Zika virus, life cycle, Small-molecule inhibitor, Treatment, Mechanism

Received: 29 Sep 2019; Accepted: 08 Nov 2019.

Copyright: © 2019 Wang, Liang, Gao, Li, Deng, Xiang, Zhang, Ying, Jiang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Tianlei Ying, Fudan University, Shanghai, 200433, Shanghai Municipality, China,
Prof. Shibo Jiang, Fudan University, Shanghai, 200433, Shanghai Municipality, China,
Dr. Fei Yu, Hebei Agricultural University, Bao Ding, China,