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REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1395403

The immunopathogenesis of Helicobacter pylori-induced gastric cancer: A narrative review

Provisionally accepted
Maryam Shirani Maryam Shirani 1Saeedeh Shariati Saeedeh Shariati 1Monireh Bazdar Monireh Bazdar 2Faezeh Sojoudi Ghamnak Faezeh Sojoudi Ghamnak 3Melika Moradi Melika Moradi 4Reyhane Shams Khozani Reyhane Shams Khozani 5Elahe Taki Elahe Taki 6Zahra Arabsorkhi Zahra Arabsorkhi 7Mohsen Heidary Mohsen Heidary 8*Dorsa B. Eskandari Dorsa B. Eskandari 9
  • 1 Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Ahvaz, Iran
  • 2 Razi Medical Education Center, Faculty of Medicine, Gilan University of Medical Sciences, Rasht, Iran
  • 3 Department of Biology, Islamic Azad University, Rasht Branch, Rasht, Gilan, Iran
  • 4 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran
  • 5 Biotechnology Research Center, Pasteur Institute of Iran (PII), Tehran, Alborz, Iran
  • 6 Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Alborz, Iran
  • 7 Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran, tehran, Iran
  • 8 Department of Laboratory Sciences, Faculty of Paramedicals, Sabzevar University of Medical Sciences, Sabzevar, Iran
  • 9 Department of Biology, Faculty of Science, Malayer University, Malayer, Iran, Hamedan, Iran

The final, formatted version of the article will be published soon.

    Helicobacter pylori (H. pylori) infection is a well-established risk factor for the development of gastric cancer (GC). Understanding the immunopathogenesis underlying this association is crucial for effective preventive and therapeutic strategies. This narrative review comprehensively explores the immunopathogenesis of H. pylori-induced GC by delving into several key aspects, emphasizing the pivotal roles played by H. pylori virulence factors including cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA), blood group antigen-binding adhesin (babA) as well as sialic acid binding adhesin (sabA). Moreover, the review focuses on the role of Toll-like receptors (TLRs) and cytokines in the complex interplay between chronic infection and gastric carcinogenesis. Lastly, the article examines the association between H. pylori evasion of the innate and adaptive immune response and development of GC (GC). A comprehensive understanding of the immunopathogenesis of H. pylori-induced GC is essential for designing targeted interventions to prevent and manage this disease. Further research is warranted to elucidate the intricate immune responses involved and identify potential therapeutic targets to improve patient outcomes.

    Keywords: Helicobacter pylori, Immunopathogenesis, gastric cancer, review, Helicobacter

    Received: 03 Mar 2024; Accepted: 06 May 2024.

    Copyright: © 2024 Shirani, Shariati, Bazdar, Sojoudi Ghamnak, Moradi, Shams Khozani, Taki, Arabsorkhi, Heidary and Eskandari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mohsen Heidary, Department of Laboratory Sciences, Faculty of Paramedicals, Sabzevar University of Medical Sciences, Sabzevar, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.