%A Amadio,Marialaura %A Scapagnini,Giovanni %A Davinelli,Sergio %A Calabrese,Vittorio %A Govoni,Stefano %A Pascale,Alessia %D 2015 %J Frontiers in Cellular Neuroscience %C %F %G English %K Heme Oxygenase-1,ELAV,Hemin,Post-tran,SH-SY5Y cells %Q %R 10.3389/fncel.2014.00459 %W %L %M %P %7 %8 2015-January-15 %9 Original Research %+ Giovanni Scapagnini,Department of Medicine and Health Sciences, University of Molise,Campobasso, Italy,g.scapagnini@gmail.com %+ Giovanni Scapagnini,Inter-University Consortium “SannioTech”,Benevento, Italy,g.scapagnini@gmail.com %# %! HO-1 mRNA is a new target of ELAV proteins %* %< %T Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1 %U https://www.frontiersin.org/articles/10.3389/fncel.2014.00459 %V 8 %0 JOURNAL ARTICLE %@ 1662-5102 %X Heme oxygenase-1 (HO-1) is an inducible rate-controlling enzyme of heme catabolism. The cytoprotective function of HO-1 activity has been verified in multiple studies, and together with its by-products is considered a key component of the cellular stress response. The transcriptional induction of HO-1 has been largely studied in response to multiple forms of stressful stimuli but our understanding of HO-1 post-transcriptional control mechanisms in neuronal cells is currently lacking. In the present report we show the involvement of the RNA-binding proteins (RBPs) embryonic lethal abnormal vision (ELAV) in the regulation of HO-1 gene expression. Our study demonstrates a specific binding between HO-1 messenger RNA (mRNA) and ELAV proteins, accompanied by an increased expression of HO-1 at protein level, in a human neuroblastoma cell line treated with hemin. Clarifying the induction of HO-1 expression at post-transcriptional level may open therapeutic perspectives for treatments associated with the modulation of HO-1 expression.