%A Hu,Wen-han %A Wang,Xiu %A Liu,Li-na %A Shao,Xiao-qiu %A Zhang,Kai %A Ma,Yan-shan %A Ai,Lin %A Li,Jun-ju %A Zhang,Jian-guo %D 2018 %J Frontiers in Neurology %C %F %G English %K MRI negative,focal cortical dysplasia,morphometric analysis program,PET/MRI co-registration,SPM-PET %Q %R 10.3389/fneur.2018.00450 %W %L %M %P %7 %8 2018-June-14 %9 Original Research %# %! Image post-processing and MRI-negative FCD %* %< %T Multimodality Image Post-processing in Detection of Extratemporal MRI-Negative Cortical Dysplasia %U https://www.frontiersin.org/articles/10.3389/fneur.2018.00450 %V 9 %0 JOURNAL ARTICLE %@ 1664-2295 %X Purpose: To determine the diagnostic value of individual image post-processing techniques in a series of patients who underwent extratemporal operations for histologically proven, MRI-negative focal cortical dysplasia (FCD).Methods: The morphometric analysis program (MAP), PET/MRI co-registration and statistical parametric mapping (SPM) analysis of PET (SPM-PET) techniques were analyzed in 33 consecutive patients. The epileptogenic zone (EZ) assumed by MAP, PET/MRI, and SPM-PET was compared with the location of the FCD lesions determined by stereoelectroencephalography (SEEG) and histopathological study. The detection rate of each modality was statistically compared.Results: Three lesions were simultaneously detected by the three post-processing methods, while two lesions were only MAP positive, and 8 were only PET/MRI positive. The detection rate of MAP, PET/MRI, SPM-PET and the combination of the three modalities was 24.2, 90.9, 57.6, and 97.0%, respectively. Taking the pathological subtype into account, no type I lesions were detected by MAP, and PET/MRI was the most sensitive method for detecting FCD types II and IIA. During a mean follow-up period of 22.94 months, seizure freedom was attained in 26/33 patients (78.8%) after focal corticectomy.Conclusions: MAP, PET/MRI, and SPM-PET provide complementary information for FCD detection, intracranial electrode design, and lesion resection. PET/MRI was particularly useful, with the highest detection rate of extratemporal MRI-negative FCD.