Corrigendum: The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent
- 1Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil
- 2Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, São Paulo, Brazil
- 3Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil
by Mendes, N. F., Pansani, A. P., Carmanhães, E. R. F., Tange, P., Meireles, J. V., Ochikubo, M., et al. (2019). Front. Neurol. 10:382. doi: 10.3389/fneur.2019.00382
In the original article, there was a mistake. In the Discussion, “Figure 5” was referenced instead of “Figure 7.”
A correction has been made to the Discussion, paragraph nine:
“In conclusion, our findings indicate that BBB breakdown is a dynamic phenomenon and time-dependent, i.e., it happens at specific time-points of the acute phase of pilocarpine model of epilepsy, recovering in part its integrity afterwards (Figure 7). We show that pilocarpine-induced changes on brain tissue initially increased the permeability of the BBB to micromolecules, and subsequently, after SE, the BBB breakdown to macromolecules occurred. Although the BBB permeability to macromolecules is restored 24 h after SE, the leakage of micromolecules persists and the consequences of BBB degradation are widely disseminated in the brain, which in turn may induce further episodes of BBB breakdown. Together, our data reveal the existence of a temporal window of BBB dysfunction during the acute phase of the pilocarpine model that is important for the development of therapeutic strategies to prevent the epileptogenesis.”
Figure 7. Representation of BBB permeability during the acute phase of the pilocarpine model. The colored bands correspond to the BBB status: intact (green band), increased permeability to micromolecules (yellow band), and breakdown to macromolecules (red band). The lines represent the dynamics of the BBB opening and restoration over time in the regions of the hippocampus (blue line), hypothalamus (yellow line), entorhinal and pyriform cortex (purple line), and neocortex (orange line). Note that increased BBB permeability for micromolecules is observed from 30 min after PILO injection, and the BBB breakdown for macromolecules occurs about 5 h after SE onset. Although the BBB permeability to macromolecules is restored 24 h after SE initiation, the leakage of micromolecules persists and the consequences of BBB degradation on brain tissue are widely disseminated in the brain.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: epilepsy, blood-brain barrier, pilocarpine, status epilepticus, Evans blue, sodium fluorescein
Citation: Mendes NF, Pansani AP, Carmanhães ERF, Tange P, Meireles JV, Ochikubo M, Chagas JR, da Silva AV, Monteiro de Castro G and Le Sueur-Maluf L (2019) Corrigendum: The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent. Front. Neurol. 10:603. doi: 10.3389/fneur.2019.00603
Received: 22 April 2019; Accepted: 22 May 2019;
Published: 10 June 2019.
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
Copyright © 2019 Mendes, Pansani, Carmanhães, Tange, Meireles, Ochikubo, Chagas, da Silva, Monteiro de Castro and Le Sueur-Maluf. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
†Present Address: Natália Ferreira Mendes, Faculdade de Enfermagem, Universidade Estadual de Campinas, Campinas, Brazil
Aline Priscila Pansani, Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, Brazil
Juliana Vieira Meireles, Unidade de Cardiologia do Exercício, Hospital Sírio Libanês, São Paulo, Brazil