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Frontiers in Neurology


Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.01022

Comorbidity of pain and depression in a lumbar disc herniation model: biochemical alterations and the effects of fluoxetine

 Lun Cai1, Qianchao He1, Yongjing Lu2, Yuying Hu1, Wei Chen1, Liping Wei1 and Yueqiang Hu1*
  • 1First Affiliated Hospital of Guangxi University of Chinese Medicine, China
  • 2People's Hospital of Guangxi Zhuang Autonomous Region, China

LDH model shows a behavioural and biochemical alterations that in accordance with the characteristic of commorbity of pain and depression and FLX improve depressive behavior and alleviate pain through increased 5-HT concentration and inhibited TNF-α mRNA expression in this model.

Keywords: Low-back pain, Lumbar disc herniation, mechanical allodynia, thermal hyperalgesia, Depression, Serotonin, TNF-α, taste preference test, forced swim test

Received: 17 Apr 2019; Accepted: 09 Sep 2019.

Copyright: © 2019 Cai, He, Lu, Hu, Chen, Wei and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yueqiang Hu, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China,