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Case Report ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.01202

Progressive multifocal leukoencephalopathy Diagnosed by Metagenomic next-Generation Sequencing of Cerebrospinal Fluid in an HIV patient

 Huan Xia1,  Yuanlin Guan2, Silvère D. ZAONGO1, Han Xia2, Ziyu Wang1, Zhongfang Yan1 and  Ping Ma1*
  • 1Department of Infectious Disease, Tianjin Second People’s Hospital, China
  • 2Independent researcher, China

Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify John Cunningham virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy.

Keywords: progressive multifocal leukoencephalopathy, metagenomic next-generation sequencing, Cerebrospinal Fluid, HIV, PML

Received: 25 May 2019; Accepted: 28 Oct 2019.

Copyright: © 2019 Xia, Guan, ZAONGO, Xia, Wang, Yan and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Ping Ma, Department of Infectious Disease, Tianjin Second People’s Hospital, Tianjin, Hebei, China,