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Front. Neurol. | doi: 10.3389/fneur.2019.01236

Anti-Hu antibody-associated Adie’s pupil and paraneoplastic sensorimotor polyneuropathy caused by primary mediastinal small cell carcinoma

 Lei Zhang1, si luo1, Xueman Lv1 and  Jiajun Chen1*
  • 1Jilin University, China

We report a woman with unilateral Adie’s pupil associated with peripheral sensorimotor polyneuropathy, elevated anti-Hu antibody and primary mediastinal small cell carcinoma (SCC). To our knowledge, this is the first report of Adie’s pupil in a patient with mediastinal SCC. Although rare, Adie’s pupil and sensorimotor polyneuropathy may be the first manifestation of cancer. Its rapid recognition facilitates an early diagnosis and treatment.

Keywords: Paraneoplastic neurological syndrome, Anti-Hu antibody, peripheral neuropathy, Adie' s pupil, small cell carcinoma

Received: 17 Jun 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 Zhang, luo, Lv and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Jiajun Chen, Jilin University, Changchun, China, cjj@jlu.edu.cn